肝母细胞瘤各组织类型的免疫表达和预后的关系

Relationship Between Immunoreaction Subtype and Prognosis in Hepatoblastoma

目的探讨肝母细胞瘤各组织类型的免疫表达和预后的关系。方法对24例肝母细胞瘤进行临床病理分析和组织学分型，其中18例作7种标记的免疫组化研究。结果胎儿型12例，胚胎型7例，间变型3例和上皮间叶混合型2例；细胞角蛋白、甲胎蛋白、S-100蛋白和波形蛋白在肿瘤上皮细胞浆的表达分别为14例、10例、9例和6例，癌胚抗原、P53和P16蛋白在细胞核中的表达分别是11例、9例和7例；手术切除肿瘤12例中8例生存期超过5年者均为胎儿型。结论肝母细胞瘤不同组织类型的免疫表达各异，并与肿瘤的分化和预后有关，胎儿型预后优于其他类型。

To investigate the relationship between immunoreaction of histologic subtype and prognosis in hepatoblastoma of chidren. Methods The clinicopathological data from 24 cases with hepatoblastoma were analysed, and immunohistochemical study was performed on 18 patients. Results There were fetal type in 12 casse, embryonal type in 7 cases, anaplasia type in 3 and mixed tupe in 2. The cytoplasmic postive expression of CK, AFP, S-100 protein and Vimentin of epithelial tumor cells were found in 14,10, 9 and 6 cases respectively. positive staining of CEA, P53 and P16 of nuclei of epithelial tumor cells were found in 11, 9 and 7 cases respectively. Among the 12 cases who underwent surgical exci-sion, 8 patients with fetal type survived over 5 years. Conclusions This study suggests that immunoreac-tion of hepatoblastomas are different in the histological subtypes. This expression may correate with the dif-ferentiation ans prognosis of the tumors.The prognosis of fetal type is better than the other histologic sub-types.