高氟摄入对大鼠骨和牙氟含量及血、尿生化指标的影响

Effects of high fluoride intake on the fluoride of femora, teeth and some biochemical indexes in rats

为了探讨能快速评价预防型抗氟剂效果的实用指标，给大鼠短期饮用高氟水（５０ｍ ｇ／Ｌ）染毒，观察氟对骨相与非骨相指标的影响。染毒１周后实验组大鼠尿Ｎ－乙酰－β－Ｄ－氨基葡萄糖苷酶（ＮＡＧ）活力、全血胆碱酯酶（ＣｈＥ）活力及尿氟含量即显著高于对照组（Ｐ＜ ０．０１）；以后３周升高的幅度不明显，但仍保持较高水平。尿羟脯氨酸、血清羟脯氨酸含量实验前后两组间未见显著差异，４周后实验组骨和牙氟含量比对照组高十几倍。本文结果表明评价预防型抗氟剂效果除必须以骨、牙氟含量为关键指标外。

In order to approach practicable indexes for assessing the effects of the products which are intended to be used to prevent endemic fluorosis, Wistar rats were fed with fluoridated water(50mg/L) for four weeks. After only one week treated with fluoride, a higher activity of NAG(N acety1 β D glucosaminidase) in urine, ChE(cholinesterase) in blood and increased urinary excretion of fluoride (compared with the control, P<0 01) were observed, and these changes were lasted to the end of the fourth week of the study, but hydroxyproline in serum and urine had not been changed in both groups. After four weeks, the fluoride levels in the femora and teeth of fluoride treated group were ten times higher than that of the control group. According to the results, fluoride in bones and teeth must be taken as key indexes, the activities of NAG in urine and ChE in blood should be taken into consideration for assessing the effects of fluoride protagonist.