血浆置换型人工肝联合内科治疗乙肝肝衰竭效果观察

The Effect of Plasma Exchange Artificial Liver Combined with Medical in Treatment of Liver Failure of Hepatitis B

目的探讨血浆置换型人工肝联合内科治疗乙肝肝衰竭的临床疗效。方法选取2005年1月-2010年9月本科收治的乙肝肝衰竭病例共109例，按照患者的意愿分为对照组（行单纯内科综合治疗）和治疗组（单纯内科综合治疗＋人工肝治疗），治疗后3个月对两组患者的总体疗效、不良反应、肝功能进行分析和比较。结果治疗组总有效率明显高于对照组（76．7％vs 55．1％），治疗组治疗后肝功能改善优于对照组，两组比较差异有统计学意义（P〈0．05）；两组患者不良反应发生率比较，差异无统计学意义（P〉0．05）。结论血浆置换型人工肝治疗乙肝肝衰竭效果显著，是安全、有效的方法。

Objective To explore the effect of plasma exchange artificial liver combined with medical treatment of liver failure of hepatitis B. Methods Form Jan. 2005 to Sep. 2010, 109 cases with liver failure of hepatitis B were divided into control group and treatment group. The control group were given medical treatment, and the treatment group were given plasma exchange artificial liver combined with medical treatment. After 3 months, the clinical effect, untoward effect and liver function were analyzed and compared. Results The total effectiveness in treatment group was higher than control group （ 76,7%VS 55.1% ）, the liver function were significantly improved in treatment group than control group （P 〈 0.05 ）. The rate of untoward effect had no significant difference between two groups （ P 〉 0.05 ）. Conclusion Plasma exchange artificial liver receive a significant effect treatment of liver fgilure of hepatitis B. It is a safe and effective method.