摘要
目的观察乌司他汀对肠手术患者术后肠黏膜屏障功能的影响。方法2010年1-12月本院普外科行肠手术患者80例，随机分为乌司他汀低剂量组和乌司他汀高剂量组各40例。手术前及手术后两组分别静脉滴注乌司他汀20万U／d和10万U／d。分别于手术前、手术后2、4天测定两组患者尿乳果糖与甘露醇的比值（L／M）、血浆谷氨酰胺（Gin）、外周血细菌DNA。结果两组患者术后L／M、Gin逐渐升高，外周血细菌DNA阳性率逐渐降低（P〈0．05）；两组间差异具有统计学意义（P〈0．05）。结论乌司他汀通过改善肠道黏膜通透性、升高Gin，对肠手术患者肠黏膜屏障功能具有明显保护作用，对预防创伤引起的肠道细菌移位具有重要临床意义。
Objective To investigate the effects of ulinastatin on intestinal mucosa barrier in patients with intestinal surgery. Methods Eighty patients with intestinal surgery who visited general surgery department from January 2010 to December 2011 were randomly divided into low dosage group and high dosage group 40 cases in each group. Cases in low dosage group or in high dosage group received 200000 U or 100000 U of ulinastatin daily before and after operation. Ratio of laetulose and mannitol in urine （L/M）, glutamine level in plasma and DNA in peripheral blood were determined before operation, 2nd and 4th day after operation. Results L/M and glutamine level in plasma were gradually increased and DNA in peripheral blood was decreased after operation （ P 〈 0.05 ）, and there were significantly different in both groups （ P 〈 0.05 ）. Conclusion Ulinastatin can protect the intestinal mucosa barrier by improving the permeability of intestinal mucosa and increase glutamine level in plasma, and prevent the endotoxin translocation from intestine caused by trauma.
出处
《中国现代医生》
2011年第21期34-35,38,共3页
China Modern Doctor
关键词
肠黏膜屏障
乌司他汀
肠手术
Intestinal mueosa barrier
Ulinastatin
Intestinal surgery
