摘要
Effects of verbascoside and martynoside on muscle contractility were investigated. Bufo gastrocnemius muscle was electrically stimulated in vitro, the amplitude and duration of the contraction were mechanically recorded and used as indices of muscle contractility. After 30 min pretreatment of muscle, verbascoside at 20.0 μmol·L -1 resisted muscle fatigue greatly. The duration at which the contraction kept at the level of 90%, 50% and 10% of its maximal amplitude(T 0.9 , T 0.5 and T 0.1 ) were prolonged by (23±10)%,(23±8)% and(31±15)%, respectively, while the maximal amplitude of contraction was not affected. Martynoside even at 80.0 μmol·L -1 improved muscle contractility slightly 〔only T 0.1 was prolonged by (14±5)%〕. The results suggest that verbascoside exhibits stronger antifatigue capacity, which may be due to its higher antioxidation activity than that of martynoside.
Effects of verbascoside and martynoside on muscle contractility were investigated. Bufo gastrocnemius muscle was electrically stimulated in vitro, the amplitude and duration of the contraction were mechanically recorded and used as indices of muscle contractility. After 30 min pretreatment of muscle, verbascoside at 20.0 μmol·L -1 resisted muscle fatigue greatly. The duration at which the contraction kept at the level of 90%, 50% and 10% of its maximal amplitude(T 0.9 , T 0.5 and T 0.1 ) were prolonged by (23±10)%,(23±8)% and(31±15)%, respectively, while the maximal amplitude of contraction was not affected. Martynoside even at 80.0 μmol·L -1 improved muscle contractility slightly 〔only T 0.1 was prolonged by (14±5)%〕. The results suggest that verbascoside exhibits stronger antifatigue capacity, which may be due to its higher antioxidation activity than that of martynoside.
出处
《中国药理学与毒理学杂志》
CAS
CSCD
北大核心
1999年第4期310-311,共2页
Chinese Journal of Pharmacology and Toxicology
关键词
毛蕊花苷
角胡麻苷
肌肉疲劳
苯丙素
糖苷类
glycosides, phenylpropanoid
verbascoside
martynoside
muscle contraction
