厄贝沙坦对慢性心力衰竭患者血浆脑钠肽及心功能的影响

Influence of irbesartan on plasma brain natriuretic peptide and cardiac function in chronic heart failure

目的：观察厄贝沙坦治疗慢性心力衰竭后,血浆脑钠肽（brain natriuretic peptide,BNP）水平的改变及心功能的改善情况。方法：选择心功能Ⅱ~Ⅳ级心衰患者48例,在常规抗心衰（扩血管药物、利尿剂及洋地黄）基础上加用厄贝沙坦,观察治疗前后血浆脑钠肽水平的变化及心功能的改变。结果：常规治疗的基础上联合应用厄贝沙坦,患者心率明显减慢,血压较治疗前降低,左室舒张末期内径（LVDd）缩短,而左室射血分数（LVEF）则较治疗前升高,血浆BNP明显降低。结论：厄贝沙坦治疗慢性心力衰竭的总有效率达90%以上,能改善心功能,增加射血分数,降低血浆BNP。

Objective：To observe plasma brain natriuretic peptide（BNP） level and the change trend of cardiac function by using irbesartan for treating chronic heart failure（CHF）.Methods：48 CHF patients with cardiac function classⅡ-Ⅳ were selected and added irbesartan on the basis of traditional treatment.Then,the changes of plasma BNP level and cardiac function before and after treatment were observed.Results：After treatment,the heart rate was significantly slowed,the blood pressure was decreased and LVDd was shortened,but LVEF was increased.The level of plasma BNP was declined significantly after use of irbesartan.Conclusion：Using irbesartan to treat CHF,the total effective rate reaches more than 90%,which could improve the cardiac function,increase LVEF and reduce plasma BNP.