低分子肝素对原发性肾病综合征高凝状态的疗效

Curative effect of low molecular weight heparin on hypercoagulable state in patients with primary nephrotic syndrome

目的:观察低分子肝素(low molecular weight heparin,LMWH)对原发性肾病综合征(primary nephroitic syndrome,PNS)高凝状态的疗效,并分析其可能作用机制。方法:将48例肾病综合征患者随机分为治疗组和对照组,对照组使用糖皮质激素,治疗组在使用激素同时加用LMWH,每12 h皮下注射5000IU,共2周,观察各项生化指标。结果:2周后,治疗组24 h尿蛋白定量、血胆固醇、血流变学各项指标均下降,与对照组比较有统计学差异(P<0.05),而肾功能(Scr)在两组间差异无统计学意义。结论:激素联合LMWH治疗PNS可改善其高凝状态、高脂血症。

Objective：To observe the curative effect of low molecular weight heparin（LMWH） on hypercoagulable state in the patients with primary nephroitic syndrome（PNS） and to analyze its possible mechanism.Methods：48 patients with PNS were randomized into treatment group and control group.The patients in the control group were given only glucocorticoids,but the patients in the treatment group were simultaneously given LMWH,5000IU by subcutaneous injection for 2 weeks,besides glucocorticoids.The clinical effects and biochemical indexes were observed.Results：Tow weeks later,24 h urinary albuminuria（UAlb）,total cholesterin and hemorheology indexes in the treatment group were significantly lower than those in the control group（P0.05）.But there was no statistic difference in renal function between the two groups.Conclusion：Using glucocorticoids combined with LMWH can improve the hypercoagulable state and hyperlipemia.