尸体肾移植术后活动性HCMV感染的预防性治疗

Prophylactic Treatment of Active HCMV Infection After Cadaveric Renal Transplantation

目的:探讨尸体肾移植术后人巨细胞病毒(HCMV)病的防治。方法:应用HCMVAg试验诊断HCMV感染。对本院实施的1150例尸体肾移植分两组进行回顾性分析。结果:治疗组:1989年9月～1997年4月共1050例,HCMV病45例,治愈30例,死亡15例;预防组:1997年5月～1998年5月,共100例,HCMV感染42例,由于进行了预防性治疗,无1例HCMV病发生和因HCMV感染而死亡。结论:HCMVAg试验可以早期诊断活动性HCMV感染,指导HCMV病的有效治疗;对活动性HCMV感染积极进行预防性治疗,能显著减少HCMV病的发生。

Objective: To explore a regimen of prophylaxis and treatment of HCMV disease after cadaveric renal transplantation. Methods:HCMV infection was diagnosed with antigenemia test 1150 cases which were divided into 2 groups were retrospectively analyzed. Results: Treated group: Among 1050 cases of cadaveric renal transplantation from September 1989 to April 1997,45 cases were diagnosed as HCMV disease; prophylactic group: Among 100 cases of cadaveric renal transplantation from May 1997 to May 1998, 42 cases were diagnosed as HCMV infection. 30 cases survived and 15 cases died from HCMV diseases after treatment with gancyclovir or foscamet in the treated group, while no one suffered from HCMV disease in the prophylactic group. Conclusion: HCMV Ag test could be used to diagnose active HCMV infection early and to guide therapy of HCMV disease effectively. Preventive therapy of active HCMV infection could significantly decrease morbidity of HCMV disease.