凉山彝族男性血管紧张素转换酶基因多态性与高血压的关系

A Study on Relationship between Hypertension and Polymorphism of ACE Gene in Male Yi People in Liangshan Yi Autonomous Prefecture, Sichuan

目的 探讨血管紧张素转换酶（ＡＣＥ） 基因多态性与高血压的关系。方法 应用横断面调查方法和ＰＣＲ 技术。结果 正常血压人群ＡＣＥ 基因ＤＤ、ＩＤ 和ＩＩ基因型分别占１３ ．０ ％ 、５０ ．９ ％ 和３６ ．１ ％ 。Ｉ和Ｄ等位基因频率分别是为６１ ．６ ％ 和３８ ．４ ％ 。高血压人群ＡＣＥ 基因ＤＤ、ＩＤ 和ＩＩ基因型分别占９ ．７ ％ 、４８ ．４ ％ 和４１ ．９ ％ 。Ｉ和Ｄ 等位基因频率分别是６６ ．１ ％ 和３３ ．９ ％ 。彝族男性高血压和正常血压人群的ＡＣＥ基因型分布及Ｉ／Ｄ 等位基因频率差异无显著性。结论 彝族男性ＡＣＥ 基因多态性与高血压的关联尚不能确定。

Objective To explore relationship between polymorphism of ACE gene and hypertension. Methods A cross sectional study was conducted and PCR technique was used to analyze gene polymorphism. Results Genotypes DD, ID and II of ACE gene accounted for 13.0% and 9.7%,50.9% and 48.4%, and 36.1% and 41.9%, respectively, in the normotensives and hypertensives. Frequencies of I and D alleles for ACE gene were 61.6% and 66.1%, and 38.4% and 33.9%, respectively, in the normotensives and hypertensives. There was no significant difference in distribution of II, ID and DD genotypes and I/D allele frequencies of ACE gene between the hypertensives and normotensives in male Yi people. Conclusion Association between polymorphism of ACE gene and hypertension was uncertain.