血尿酸水平与冠状动脉病变严重程度的相关性分析

Relationship between serum uric acid levels and the severity of coronary lesions in patients with coronary heart disease

目的 探讨血尿酸水平与冠状动脉病变严重程度的关系.方法 入选338例经冠状动脉造影检查确诊为冠心病的患者,根据冠状动脉造影结果分为单支病变组100例,双支病变组78例,多支病变组160例.测定3组空腹血尿酸、血脂、血糖等各项指标并进行比较,最后分析血尿酸与冠状动脉病变严重程度的关系.结果 单支病变组、双支病变组、多支病变组血尿酸水平分别为（299.66±50.23）、（368.97±74.49）、（415.01±82.27）μmol/L,3组差异具有统计学意义（P＜0.01）;性别、高血压、血尿酸水平、TC、LDL-C与冠心病病变严重程度具有显著相关性（P＜0.01）,年龄、吸烟、空腹血糖与冠心病病变程度具有相关性（P＜0.05）,而TG、HDL-C与冠心病病变严重程度无相关性（P ＞0.05）.进一步采用偏相关分析,剔除性别、年龄、吸烟、高血压、空腹血糖、TC、LDL-C对冠心病病变严重程度的影响后,血尿酸水平与冠心病病变严重程度仍具有显著相关性（P＜0.01）;最后进行线性回归分析,得回归方程y=0.104＋0.006x.结论 血尿酸水平与冠状动脉病变的严重程度密切相关,检测血尿酸水平有可能成为一项有价值的、能预测冠心病事件的常规检查方法.

Objective To investigate the relationship between the serum uric acid levels and the severity of coronary lesions in patients with coronary heart disease. Methods Three hundred and thirty eight patients who underwent coronary angiography were classified as single-vessel disease group （n=100）, double-vessel disease groups（n=76） and triple-vessel disease groups （n=160） according to the number of vessels with significant stenosis. The serum uric acid levels and other clinical biochemical parameters were detected, and the relationship between the serum uric acid level and coronary lesions were analyzed. Results The serum uric acid levels of single-vessel disease group, doublevessel disease group and triple-vessel disease group were （291.66 ± 50.23）, （368.97 ± 74.49）and （415.01 ± 82.27） μ mol/L, respectively （P〈0.01）. Bivariate Correlations analysis revealed that serum uric acid was significantly associated with coronary lesions （P〈0.01）. The total cholesterol（TC ）, low density lipoprotein cholesterol（LDL-C ）, hypertension and sex were also significantly associated with coronary lesions （P〈0.01） and age, smoking, diabetes were relevant with coronary lesions （P〈0.05）. But triglycerides （TG）, high density lipoprotein cholesterol （HDL-C）were not associated with coronary lesions （P 〉 0.05）. The further Partial Correlations analysis showed that serum uric acid was significantly associated with coronary lesions after other risk factors were adjusted. Linear Regression analysis revealed the linear regression equation as y=0.104＋0.006x. Conclusion Serum uric acid levels are correlated with atherosclerotic heart disease and the severity of coronary lesions, which indicates that the measurement of serum uric acid may be of value in predicting coronary heart disease events.