摘要
目的 探讨注意缺损多动障碍(ADHD) 与多巴胺转运体(DAT1) 基因间的关系。方法 分别采用基于单体型和基于基因型的单体型相对风险分析方法,在上海地区汉族人群中对ADHD 与DAT1 基因微卫星多态性进行遗传关联分析。结果 ①上海地区汉族人中,DAT1 基因多态以480 bp 重复片段为主,其基因频率为92% 。②以父母双亲为对照,经GHRR 和HHRR 分析,DAT1 基因与ADHD 均无关联。结论 上海地区汉族人群中DAT1 基因多态与ADHD 无关。
Objective The present study was designed to investigate the relationship between attention deficit hyperactivity disorder (ADHD) and minisatellite polymorphism of dopamine transporter 1 gene (DAT1 gene) in the Han population in Shanghai. Methods The haplotype based haplotype relative risk (HHRR) and genotype based haplotype relative risk (GHRR) methods were used to analyzed the relationship in 74 ADHD children and their parents. Results In our samples, 10 repeats (480 bp) were the dominant allele of DAT1 minisatellite polymorphisms with the allele frequency 0.92, and we found no significant association between the DAT1 minisatellite polymorphism and ADHD ( P>0.05 ). Conclusions Our results do not support that ADHD is associated with the DAT1 minisatellite polymorphism in the Han population in Shanghai.
出处
《中国神经精神疾病杂志》
CAS
CSCD
北大核心
1999年第6期355-357,共3页
Chinese Journal of Nervous and Mental Diseases
关键词
多动症
ADHD
多巴胺转运体
DAT基因
儿童
ADHD DAT1 gene Haplotype based haplotype relative risk Genotype based haplotype relative risk