维生素A、更生霉素对胚胎高热致畸影响的实验研究

Experimental study on synergetic teratogenesis action between hyperthermia and vitamin A,dactinomycine

目的：探讨维生素Ａ和更生霉素与胚胎高热致畸的协同作用。方法：动物实验研究。结果：致畸剂量的维生素Ａ 和低于致畸剂量的更生霉素分别与高热共同作用所致的畸胎、死胎、吸收胎发生率及胚胎发育迟缓程度均显著高于其对应的单因素作用组。结论：多种小剂量致畸原同时存在、共同作用时，可抑制胚胎的修复能力，从而发生协同作用。

Objective:To probe into the synergetic teratogenic action on mouce embryoes between hyperthermia and observed factors (Vitamin A and dactinomycine).Methods:It was an experimental study on mice.Results:In the two factor groups,the teratogenic rates,absorbed embryo rates and still embryo rates were significantly higher than those in single factor groups,and the means of weight,length and tail length were significantly lower than those in single factor groups.Conclusion:Vitamin A and hyperthermia have synergetic effect on embryo development,so do dactinomycine and hyperthermia.Various minor teratogens should have synergetic teratogenic effect and cause birth defects.