首乌藤黄酮的体内抗氧化作用研究

Study on antioxidation effect in vivo of flavonoids from Caulis Polygoni Multiflori

为研究首乌藤黄酮(flavonoids fromCaulis Polygoni Multiflori,简称FCPM)的体内抗氧化作用,将ICR小鼠自由分成四组,分别灌喂高、中、低剂量FCPM和生理盐水,30 d后眼眶采血及组织取样,用试剂盒测定小鼠血清、肝脏、脑组织中MDA含量、SOD和GSH-PX酶活性及血清、肝脏中CAT酶活性.结果表明,FCPM可显著降低血清及组织MDA含量,提高小鼠的血清及组织的SOD、GSH-PX和CAT活力,表明FCPM具有显著的体内抗氧化活性.

To study the antioxidation effect in vivo of flavonoids from Caulis Polygoni Multiflori（FCPM）,ICR mices were randomly divided into 4 group（stomach irritation with high/middle/low FCPM and salineonly）,contents malondialdehyde（MDA）,enzyme activities of superoxide dismutase（SOD） and glutathione peroxidase（GSH-PX） in the serum,liver/brain and enzyme activities of Catalase（CAT） in the serum,liver of ICR mice were measured by reagent box.The results showed that FCPM can significantly increase the activity of SOD/GSH-PX in the serum,liver/brain and increase the activity of CAT in the serum/liver,decrease the contents of MDA in the serum and the organs.FCPM can improve antioxidation ability in vivo and balance the state of antioxidation/oxidation.