类风湿性关节炎两种不同证型与三种可溶性细胞因子受体之间关系的探讨

Study on Relationship between Two Different Syndromes and Three Soluble Cytokine Receptors in Patients with Rheumatoid Arthritis

目的:探讨痹证中类风湿性关节炎(RA)的两种证型(寒湿阻络证和湿热阻络证)与3种可溶性细胞因子受体(sCKR),即可溶性白细胞介素2、6受体(sIL2R、sIL6R)、可溶性肿瘤坏死因子受体(sTNFR1)之间的关系。方法:用ELISA法测定两证型患者血清中3种sCKR。结果:RA患者中3种sCKR均显著高于健康人,经治疗后均显著下降;寒湿阻络证sIL2R显著高于湿热阻络证,而sTNFR1显著低于湿热阻络证,sIL6R则两证型患者未见明显差异。结论:RA寒湿阻络证患者可能以sIL2R的显著升高和sTNFR1的明显降低为特征,湿热阻络证患者可能以sTNFR1的显著升高和sIL2R的显著降低为主。

Objective: To study the relationship between two different Syndromes (Cold Damp Syndrome and Damp Heat Syndrome) and three soluble cytokine receptors (sCKR, soluble interleukin 2 receptor, sIL 2R, soluble interleukin 6 receptor, sIL 6R, soluble tumor necrosis factor receptor 1, sTNFR 1) in rheumatoid arthritis (RA). Methods: The serum levels of three soluble receptors were measured by ELISA in patients with RA. Results: The serum levels of 3 sCKR were significantly elevated in RA patients compared to healthy controls and obviously lowered after treatment (P<0 01). The level of sIL 2R was significantly higher in Cold Damp Syndrome than that in Damp Heat Syndrome (P<0 01), but serum sTNFR 1 was significantly higher in Damp Heat Syndrome than that in Cold Damp Syndrome, there was no obvious difference between sIL 6R of two Syndromes. Conclusion: The high serum sIL 2R and low sTNFR 1 might be a cirterion of Cold Damp Syndrome, but the high sTNFR 1 and low sIL 2R might be a criterion of Damp Heat Syndrome, these criteria reflected some states of different functions in immune system in patients with RA.