服毒患者胃粘膜损伤的初步观察

Preliminary observation of gastric mucosa lesion in patients taking poison

目的 探讨部分毒物内服时对人胃粘膜的损伤及其规律性。方法 对１６４ 例内服毒物自杀的患者在洗胃后即时由专人操作内窥镜查，观察胃底、胃体、胃窦部，分别在以上各处钳取粘膜组织２～６ 块，ＨＥ染色镜检，对内镜观察结果分级分度，对８ 例患者进行了１０ｄ ～６ｍｏ 的随访。结果 １６４ 例１００ ％ 异常，对照组中１８ 例异常（１８ ．０％ ），两组比较有显著性差异（ Ｐ＜ ０．０１），胃粘膜病变为具有特征性的急性出血性糜烂性胃炎，随着中毒症状的恶化、内服毒物量的增加及毒性的上升，胃粘膜损伤加重，随着病情的改善而改善。结论 粘膜损伤是毒物内服时全身病变的一部分。

Objective To study the regularity about gastric mucosa lesion in mankind having taken a part of posion.Methods Usning the gastrasicopy and biopsy,the changes of gastric mucosa were investigated on 164 patients taking poison(male 54 cases,famale 110cases,aged from 15 to 32 years),and 100 cases of normal(male 34 cases,famale 66 cases,aged from 18 to 35 years).GIS-105 gastroscopy made in shanghai was used and operated for sole duty.The gastric mucosa in fundus antrum and copus were taken and stained with hemotoxylin and eosin(HE),and the results were compared with normal persons.The gastric mucosa lesion in 8 patients were followed up from 10d to 6 mon).Results The abnormal rate of gastric mucosa was 100% in patients taking poison and 18.0% in control group (P<0.01).The characteristic changes of gastric mucosa in patients taking poison were acute hemorrhagic/erosion gastritis.The pathological changes of patients were worsened with poisoning symptoms and dosage of poison agent and improved with patients condition botter correspondingly.Conclusion The pathological lesion of gastric mucosa is a part of the whole body in patient taking poison.