江苏省耐药结核病抽样调查研究

Epidemiology of anti-tuberculosis drug resistance in Jiangsu province

目的:了解江苏省耐药结核病流行状况,为江苏省结核病防治规划修订和完善提供科学依据。方法:按WHO/IU-ATLD《结核病耐药监测指南》要求进行抽样和药物敏感性检测。结果:①江苏省肺结核患者总耐药率为40.96%,初始耐药率为32.80%,获得性耐药率为55.90%;总耐多药率16.61%,初始耐多药率7.63%,获得性耐多药率33.07%;②不同年龄组、不同学历、不同地区和是否有中断史的肺结核患者的耐药分布有差异。结论:江苏省肺结核患者的耐药情况不容乐观,需要引起重视。耐药主要发生在经济欠发达地区,以中年和文化程度低者为主,有中断治疗史患者发生耐药危险较高。

Objective：To evaluate the prevalence of anti-tuberculosis drug resistance（DR） among tuberculosis（TB） patients in Jiangsu province and provide statistical data for government to prevent and control TB.Methods：The TB patients in Jiangsu province were sampled and drug susceptibility test（DST） was carried out according to the ＂Guidelines for surveillance of drug resistance in tuberculosis＂ developed by WHO/IUATLD.Results：①The DST results showed that 40.96% Mycobacteria tuberculosis strains were resistant to at least one drug we tested,and the proportion was 32.80% among new cases and 55.90% among previously treated ones.The prevalence of multidrug-resistant（MDR） TB was 16.61%,with a significant difference in new cases（7.63%） and in previously treated cases（33.07%）.② Patients in middle-age or with lower education background or living in the middle or north part of Jiangsu province had higher risks for DR or MDR.Conclusion：The high prevalence of drug resistance in Jiangsu province has been a major challenge for TB control.