手术治疗局限期小细胞肺癌患者的多因素预后分析

The multivariate analysis of prognosis in limited small cell lung cancer patients who underwent surgery

目的:探讨手术在局限期小细胞肺癌(SCLC)治疗中的作用,并分析影响其预后的因素,为小细胞肺癌手术治疗提供科学依据。方法:对本院1985年1月～2005年12月间收治的,且组织学病理以及影像学明确诊断为局限期小细胞肺癌的70例手术患者进行生存时间的分析,经Kaplan-Meier生存分析、Cox回归分析等方法,探讨影响小细胞肺癌手术疗效的相关预后因素。结果:本组SCLC手术患者Ⅰ期、Ⅱ期以及Ⅲ期的5年生存率分别为63.8%、40.1%、33.2%。Cox单因素以及多因素分析表明:TNM分期、是否行化疗、手术方式和KPS评分是影响SCLC患者手术预后的独立危险因素。结论:以手术为主的治疗能使局限期SCLC患者受益,且TNM分期、是否行化疗、患者KPS评分是影响其预后的独立危险因素。

Objective：To explore the potential role of the surgical treatment in limited small cell lung cancer（SCLC） and analyze the factors affecting the prognosis.Methods：From January 1985 to December 2005,the survival rate of 70 in-patients with limited SCLC confirmed by histological pathology and imaging were analyzed.Furthermore,the related prognostic factors of patients underwent surgery were investigated by Kaplan-Meier estimator and Cox regression analysis.Results：The five-year survival rates of patients with stage Ⅰ,Ⅱ,Ⅲ SCLC were 63.8%,40.1% and 33.2%,respectively.The Cox regression analysis indicated that TNM stage,application of platinum-based chemotherapy,operative manner and KPS scores were independent prognostic factors for SCLC patients after surgery.Conclusion：Patients with limited SCLC may benefit from the comprehensive treatment based on surgery.TNM stage,application of platinum-based chemotherapy,operative manner and KPS scores were independent prognostic factors for SCLC patients after surgery.