非小细胞肺癌VEGFR-2的表达及临床意义

Expression and prognostic significance of the VEGFR-2 gene in human parenchyma of NSCLC

目的:探讨血管内皮生长因子受体-2(vascular endothelial growth factor receptor 2,VEGFR-2)在非小细胞肺癌(non-small-cell lung cancer,NSCLC)中的表达及其与临床病理特征、预后的关系。方法:采用组织芯片技术和免疫组织化学方法检测VEGFR-2在217例非小细胞肺癌中的表达情况,并结合临床病理资料进行单因素生存分析。结果:VEGFR-2在NSCLC中高表达,阳性率为63.1%,且该基因的表达与肿瘤分化程度、TNM分期、淋巴结转移、神经侵袭有显著相关性(P<0.05)。VEGFR-2的表达与NSCLC的预后相关,阳性表达该基因的患者的平均中位生存期比阴性表达的患者长12个月(P=0.049)。结论:VEGFR-2基因在非小细胞肺癌的发生、发展过程及预后具有重要作用。

Objective：To explore the prognosis of VEGFR-2 expression and its correlation with the clinical pathological characteris-tics in the parenchyma of NSCLC.Methods：The tissue microarray（TMA） technique and immunohistochemistry stain were used to detect the expression of VEGFR-2 protein in 217 non-small cell lung cancer tissues.Results：The positive expression rate of VEGFR-2 in parenchyma of NSCLC is 63.1%.And the gene expression was significantly correlated with tumor differentiation,TNM stage,lymph node metastasis and perineural invasion（P 〈 0.05）.Moreover,the median survival for patients with the positive expression of VEGFR-2 was longer by 12 months than that for patients with negative expression（P 〈 0.049）.Conclusion：VEGFR-2 plays an im-portant role in the genesis,devedopment and prognosis of non-small cell lung cancer.