恶性血液病患者游离Fas的检测及意义

THE SERUM LEVELS OF SOLUBLE FAS IN PATIENTS WITH MALIGNANT HEMATOLOGIC DISEASE AND ITS CLINICAL IMPLICATION

目的 了解游离Ｆａｓ（ｓＦａｓ）在恶性血液病中的水平及临床意义。方法 用酶联免疫吸附法测定６０ 例恶性血液病患者血清中ｓＦａｓ水平。结果 恶性血液病患者血清ｓＦａｓ水平高于正常人，治疗后ｓＦａｓ水平下降，下降的程度与疗效有关，但治疗前水平高低与疗效无关。结论 ｓＦａｓ对恶性血液病的诊断及疗效判定有一定意义，并可能对其发病机制产生影响。

Objective To study the serum levels of soluble Fas (sFas) in maglinant hematologic disease and its clinical implication.Methods Using sandwich enzyme linked immunosorbent assay(ELISA) method,we measured the serum levels of sFas in 60 patients with malignant hematologic disease and in a control group of 30 health volunteers. Results 1. Before chemotherapy,the serum levels of sFas in patients with malignant hematologic disease were singificantly higher than that of control group(P<0.01),and those were not related to respose to chemotherapy.2.After chemotherapy,the levels of sFas significantly lowered in complete remission (CR) group(P<0.05),but did not in unremission (NR) group. Conclusion The levels and changes of sFas may be served as a reference finger to diagnosis some malignant hematological disease and to evaluate chemotherapy effect.sFas may be involved in pathogenesis of some malignant hematological disease.