甘露醇治疗急性脑血管病致肾损害疗效探讨

目的分析甘露醇治疗急性脑血管病致肾损害的临床体会。方法 60例急性脑血管病患者根据其具体情况,在严密监护下,给予小剂量甘露醇治疗。结果 (1)治疗后急性肾衰竭发生率为18.3%,死亡率为8.3%。(2)治疗前后UIAb、Uβ2-MG、UIgG等均有非常显著性升高(P<0.01)。(3)治疗3d后急性肾衰竭患者上述指标显著高于非急性肾衰竭患者(P<0.05)。结论应用甘露醇应该以小剂量为宜,并联合多指标综合监测,从而保证治疗效果,提高临床用药安全性。

Objective To explore t clinical experience on renal impairment caused by mannitol treatment of ACVD.Methods 60 cases of patients with ACVD were given small dose of mannitol and strict monitoring according the concrete conditions.Results（1） The incidence of ARF was 18.3%,and death rate of ARF was 8.3%.（2） Before and after treatment,the UIAb、Uβ2-MG、UIgG increased very significantly（P0.01）.（3） after 3 days of treatment,ARF patients compared with N-ARF patients,UIAb、Uβ2-MG、UIgG were significantly higher（P0.05） Conclusion The using of mannitol should be small dose,and combine with comprehensive monitoring of indexes,to guarantee clinical effect and enhance safety.