病毒性乙型肝炎与病毒性丁型肝炎的红细胞免疫

Red cell immune function in patients with viral hepatitis B and hepatitis D

[目的 ]探讨病毒性丁型肝炎的红细胞免疫 .[方法 ]应用红细胞C3b受体花环试验、红细胞免疫复合物花环实验、红细胞免疫粘附促进因子和抑制因子试验的方法检测丁型肝炎与乙型肝炎的红细胞免疫 .[结果 ]10 4例乙型肝炎患者血清中丁型肝炎标志物总感染率为 2 5.0 0 % ,其中慢性肝炎、肝硬化时丁型肝炎标志物阳性率明显高于急性肝炎 ;慢性丁型肝炎、肝硬化患者C3b受体花环率较正常对照组降低 ,且慢性丁型肝炎患者C3b受体花环率较慢性乙型肝炎组下降 .[结论 ]红细胞免疫参与丁型肝炎和乙型肝炎的发病机理 ,并且乙型肝炎病毒及丁型肝炎病毒混合感染与临床症状的慢性化、恶性化有密切联系 .

OBJECTIVE To probe into the red cell immune function in viral hepatitis D. METHODS The red cell immune functions in viral hepatitis B and D were detected by using the methods of red cell C 3b receptor rosette (RC 3bRR), red cell immune complex rosette,and RBC immune adherence inhibitor factor. RESULTS In 104 cases of patient's serums of viral hepatitis B.The overal positive rate in the hepatitis D virus markers was 25.00%, RBC immune adherence enhance factor and inhibitor factor in which the positive rate of the HDVM in chronic hepatitis and liver cirrhosis were significantly higher than that in acute hepatitis. The RC 3bRR in chronic hepatitis D and liver cirrhosis was more decrease than that in the normal group and chronic hepatitis B. CONCLUSION It was pointed out that the change of red cell immune function probably affects the pathogenesis of hepatitis D and hepatitis B, and HBV/HDV mixed infections were correlative with the pathogenesis of chronic hepatitis and the exacerbation of liver disease.