肿瘤患者血清铜锌及其比值测定的意义

Evaluation of the Serum Copper Zinc Levels and Copper/Zinc Ratio in the Diagnsis of Malignant Tumor

[目的]探讨恶性肿瘤患者血清铜、锌水平和铜／锌比值的应用价值。[方法]本文采用美国PE公司3030型原子吸收分光光度计，对1230例恶性肿瘤患者，210例良性疾病患者和100例健康成人，进行血清铜、锌水平和铜／锌比值的测定。[结果]恶性肿瘤患者血清铜水平和铜、锌比值明显高于良性疾病组和健康对照组，而血清锌低于健康对照组，有统计学意义。血清铜／锌比值对卵巢癌诊断阳性率为81．48％；宫颈癌为71．0％；肝癌为78．26％；胃癌为68．00％；食管癌为64．66％；直肠癌为58．00％；肺癌为64．75％；恶性淋巴瘤为57．83％。铜／锌比值对恶性肿瘤的诊断灵敏度为68．93％。[结论]血清铜／锌比值对恶性肿瘤的鉴别诊断有重要的意义，并且该方法简便、经济，对从高发区高危人群中筛选癌症患者具有一定的应用价值。

[Purpose]To explore the applicable Value of copper/zinc ratio in malignant tumor. [Methods]Serum Zinc(Zn)serum, Copper(Cu),and the Cu/Zn raio were detemined by atomic absorption spectrophotometry in 1230 peients with malignant tumors(lung cancer, ovarian caner,cervical cancer, esophgeal cancer, stomach cancer, liver caner, rectum cancer and malignant lymphoma), 210 patients with benign diseases and 100healthy subjects. [Results]The result showed that the serum Cu level and Cu/Zn ratio were significantly higher and serum Zn level was significantly lower in the malignant tumor groups than that in the benign disease groups,and in the healthy normal control group (P < 0.01,respectively). At a cutoff value of 1.10, Cu/Zn ratio positive predictive value were 64.75%,81.48%,71.0%,64.66%,68%,78%, 58.00% and 57. 83% for the every aforementioned group patients with malignant tumor respectively.The sensitivity were 68. 93% between malignant tumor groups and healthy subjects. [Conclusion]Cu/Zn ratio may provide a useful parameter for patients with malignant tumor in monitoring and diagnosis.