普乐林对溴氰菊酯中毒豚鼠心血管毒性的保护作用

Protective effects of puerarin against cardiovascular toxicity caused by deltamethrin in guinea pigs

目的 探讨溴氰菊酯的心血管毒性及普乐林的保护作用。方法 将豚鼠随机分成溴氰菊酯染毒组、普乐林治疗组以及芝麻油对照组， 应用生理多导记录仪研究其心血管功能的变化。结果 溴氰菊酯染毒后豚鼠血压升高、收缩力加强和心率减慢； 心电图表现为ＱＴｒ 增大、ＱＲＳ 间期延长、ＳＴ 段压低、Ｔ 波加深以及多种心律失常。经普乐林治疗后中毒豚鼠除ＱＴｒ 仍一时性增加外， 其它心血管功能未见明显改变。结论 普乐林对溴氰菊酯中毒豚鼠的心血管毒性具有保护作用。

Objective To study cardiovascular toxicity of deltamethrin and protective effect of puerarin on it.Methods Guninea pigs were randomly divided into three groups,i.e.,Group 1 exposed to deltemethrin 25 mg/kg intraperitoneally without treatment,Group 2 treated with puerarin 10 mg/kg after exposure to deltamethrin,and Group 3 as control.Cardiovascular functions of the animals in each group were examined with a physiological polygraph.Results Blood pressure increased,myocardial contraction strengthened and heart rate slowed down in the animals exposed to deltamethrin.Electrocardiograms showed their Q T interval and QRS complex prolonged,S T segment lowered,T wave deepened down,as well as varied arrhythmia observed.After treatment with puerarin,there were no significant changes in cardiovascular functions in exposed guinea pigs except for transient increase of Q T interval.Conclusion It suggests that puerarin can protect guinea pigs from cardiovascular toxicity caused by deltamethrin.