先天性马蹄足的相关基础研究

The Related Basic Research of Congenital Clubfoot.

目的 :通过对相关文献的回顾 ,了解先天性马蹄内翻足 (CCF)病因 ,病理及发病机制的研究现状 ,明确将来的研究方向。方法 :所有文献对CCF的病因、病理及发病机制进行了较详细的阐述 ,包括 :解剖学、组织学、免疫组织化学。光镜及电子显微镜观察、计算机分析及流行病学调查等研究方法。结果 :患肢的骨骼、神经肌肉、纤维结缔组织等均有不同程度的病理变化。结论 :CCF与神经肌肉的病变 ,足跗骨的异常 ,纤维结缔组织的改变及遗传、出生季节等因素有关。

Objective:To understand current study in pathogeny,pathology and mechanism of CCF and discuss the research direction in future by related references review.Method:The references involved pathogeny,pathology and mechanism of CCF were explicit in aspects of anatomy,histology histochemistry microscope electronmicroscope,computer analysis and epidemiological investigation.Result:The bones nerves,muscles and fibroconnective tissue of affected limbs showed pathological changes in different extent.Conclusion:The occurrences of CCf are related to pathological changes of nerves,muscles tarsus,and fibroconnective tissue,heredity and birth season.