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II期结肠癌术后辅助化疗进展 被引量:6

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摘要 结肠癌是最常见的恶性肿瘤之一。Ⅲ期结肠癌根治术后采用含氟尿嘧啶(5一FU)的辅助化疗已经成为标准的治疗.而Ⅱ期结肠癌患者术后是否进行辅助化疗、如何选用合适的化疗尚存在争议。因为多项研究发现.Ⅱ期结肠癌患者从术后辅助化疔中获益的比例仅为2%~5%。如何甄别出能够从辅助化疗中真正获益的患者.并且提供合适的化疗.是临床的焦点问题。
出处 《中华胃肠外科杂志》 CAS 北大核心 2011年第8期653-656,共4页 Chinese Journal of Gastrointestinal Surgery
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  • 1Figueredo A, Charette ML, Maroun J, et al. Adjuvant therapy for stage II colon cancer: a systematic review from the Cancer Care Ontario Program in evidence-based care's gastrointestinal cancer disease site group. J Clin Oncol, 2004,22(16):3395- 3407.
  • 2Quasar Collaborative Group, Gray R, Bamwell J, et al. Adjuvant chemotherapy versus observation in patients with colorectal cancer: a randomised study. Lancet, 2007,370 (9604) : 2020-2029.
  • 3Andre T, Boni C, Navarro M, et al. Improved overall survival with oxaliplatin, fluorouracil, and leucovorin as adjuvant treatment in stage II or III colon cancer in the MOSAIC trial. J Clin Oncol, 2009,27(19) :3109-3116.
  • 4Sargent D, Sobrero A, Grothey A, et al. Evidence for cure by adjuvant therapy in colon cancer: observations based on individual patient data from 20,898 patients on 18 randomized trials. J Clin Oncol, 2009,27(6):872-877.
  • 5Rosenberg R, Maak M, Nitsche U, et al. Independent validation of a prognostic genomic profile (ColonPrint) for stage II colon cancer (CC) patients. 2010 ASCO meeting. J Clin Oncol, 2010,18:abstr 3513.
  • 6Wilson PM, Ladner RD, Lenz HJ. Predictive and prognostic markers in colorectal cancer. Gastrointest Cancer Res, 2007,1 (6) : 237-246.
  • 7Ribic CM, Sargent DJ, Moore MJ, et al. Tumor microsatellite- instability status as a predictor of benefit from fluorouracilbased adjuvant chemotherapy for colon cancer. N Engl J Med, 2003,349 (3) : 247-257.
  • 8Sargent DJ, Marsoni S, Thibodeau SN, et al. Confirmation of deficient mismatch repair (dMMR) as a predictive marker for lack of benefit from 5-FU based chemotherapy in stage Ⅱ and Ⅲ colon cancer (CC): A pooled molecular reanalysis of randomized chemotherapy trials. 2008 ASCO Annual Meeting Proceedings. J Clin Oncol, 2008,26 : abstr 4008.
  • 9Hutchins G, Southward K, Handley K, et al. Value of mismatch repair, KRAS, and BRAF mutations in predicting recurrence and benefits from chemotherapy in colorectal cancer. J Clin Oncol, 2011,29(10) : 1261-1270.
  • 10Sinicrope F, Foster NR, Sargent DJ, et al. DNA mismatch repair status and site of tumor recurrence in stage II and III colon cancers treated in 5-fluorouracil-based adjuvant therapy trials. J Clin Oncol, 2010,28 : ahstr 3519.

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