细菌性阴道病与宫颈异常上皮细胞的研究

Study of association between the bacterial vaginosis and the abnormal epithelial cell of cervix

目的探讨细菌性阴道病(BV)与宫颈异常上皮细胞之间的关系。方法 2008年11月～2009年2月湘雅医院妇科门诊经TC T诊断为的宫颈异常上皮细胞患者46例作为研究组(其中ASC-U S 6例,LSIL 12例,H SIL 19例,鳞癌9例),另同期经TC T诊断为慢性宫颈炎症的患者中随机抽取100例作为对照组,所有病人均取阴道分泌物行革兰染色N ugent评分、宫颈分泌物H PV16、18检测,比较两组BV和H PV16、18的感染率。结果①BV(+)在研究组中发病率为52.17%,明显高于对照组10%(P<0.05);②宫颈H PV16、18(+)研究组为60.87%,明显高于对照组3%(P<0.05);③BV(+)合并H PV16、18(+)的,研究组为41.30﹪,对照组为0,差异有显著性(P<0.05)。BV(-)且H PV16、18(-)的,研究组为28.26﹪,对照组为87﹪,差异有显著性(P<0.05)。结论 BV可能促进宫颈异常上皮细胞的发生发展;BV可能增加H PV16、18的感染。

【Objective】 To analyze the association between bacterial vaginosis（BV） and cervical lesion.【Methods】 We retrospectively collected the materials between November 2008 and February 2009 in the XiangYa Hospital of Central South University.All patients were divided into two groups according TCT result,the study group were 46 patients with the abnormal epithelial cell of cervix（there are 6 cases ASC-US,12 cases LSIL,19 cases HSIL and 9 cases cervical cancer） and the control group were 100 cervicitis patients.We used Nugent＇s criteria to diagnose BV and HPV16,18 was carried out by polymerase chain reaction（PCR）.【Results】 The incidence of BV（＋） in study group was 52.17% while in control group was 10%,which was statistical significance（P 0.05）.HPV16,18（＋） also had statistical significance（P 0.05）,which was 60.87% in study group while 3% in control group.The patients in study group（41.30%） who had both BV（＋） and HPV16,18（＋） infection was higher then the control group（0）（P 0.05）.The patients in study group（28.26%） who had both BV（-） and HPV16,18（-） infection was lower then the control group（87%）（P 0.05）.【Conclusions】 BV might promote the invasion of the abnormal epithelial cell of cervix.BV also might increase the infection of HPV16,18.