多层螺旋CT评估他汀类药物治疗冠状动脉斑块疗效的临床价值研究

Clinical value study of multi-slice spiral computed tomography evaluation of the effects of statins on coronary atherosclerotic plaque

目的利用16层螺旋C T影像学资料来评估氟伐他汀治疗冠状动脉斑块的疗效,并研究其临床应用价值。方法选择经16层螺旋C T检查发现的冠状动脉粥样斑块患者89例氟伐他汀治疗12个月后,用16层螺旋C T复查其斑块变化情况;并检测其血脂变化情况。结果 89例患者血脂4项中TC、LD L-C和TG均有不同程度的下降(差异有显著性),其中以LD L-C下降最明显;而H D L-C略有增加(差异无显著性)。224个4种不同的粥样斑块中脂质斑块、纤维斑块和混合斑块均有明显缩小(差异有显著性),其中以脂质斑块缩小最明显;而钙化斑块略有缩小(差异无显著性)。结论多层螺旋C T具有无创和多角度显示等优点,是诊断冠状动脉粥样斑块实用而重要的检查手段,具有较好的临床应用价值。合理使用他汀类药物治疗能逆转冠状动脉粥样斑块,是防止急性冠状动脉事件的发生的极为有效的治疗措施。

【Objective】 To evaluate the effects of fluvastatin on plaque of coronary atheroma by 16-slice spiral computed tomography.【Methods】 89 cases of coronary atheroma were examined with 16-slice spiral computed tomography,received fluvastatin tablets for 12 months and rescaning coronary atheroma again.And the blood lipid at the same time was reviewed.【Results】 TC,LDL-C,TG of the 89 cases had different degree of reduce,LDL-C was reduced obviously（difference of statistics）;HDL-C was increased slightly（not difference of statistics）.Lipoid plaques,fibrous plaques,mixed plaques of 224 coronary artery plaques had different degrees of descent,Lipoid plaques was reduced obviously（difference of statistics）;calcified plaques was reduced slightly（not difference of statistics）.【Conclusion】 Reasonable administration fluvastatin statin reduce hyperlipi-daemia,slow progression of coronary atheroma and improve the clinical outcomes.MDCT can quanti-tatively evaluate the changes of coronary atheroma.It provides the objective basis for clinic treatment.