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28例成人维生素K缺乏症的临床分析 被引量：1

Clinical analysis of 28 patients with adults Vitamin K Deficiency
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摘要 目的分析成人维生素K缺乏症的临床特点、实验室检查和治疗。方法回顾性分析28例成人维生素K缺乏症患者的临床特点及维生素K1治疗前后凝血功能的变化。结果应用维生素K1治疗后,凝血酶原时间(PT)和活化部分凝血活酶时间(APTT)较治疗前明显缩短(P<0.01)。结论这类患者病史隐匿,容易误诊,检测PT和APTT对于成人维生素K缺乏症的诊断及疗效监测具有重要价值,应尽早给予患者维生素K1治疗。 【Objective】 To analyze the clinical characteristics,laboratory and treatment in adults Vitamin K Deficiency.【Methods】 Retrospective analysis were performed on the data of clinical manifestations and the variation of coagulation prior to and after Vitamin K1 therapy of 28 patients with adults Vitamin K Deficiency.【Results】 After Vitamin K1 therapy,prothrombin time（PT） and activated partial thromboplastin time（APTT） reduced significantly（P 0.01）.【Conclusions】 The kind of coagulation disorders is prone to be neglected for insidious medical history,monitoring PT and APTT may contribute to the diagnosis and therapeutic effect of adults Vitamin K Deficiency,Vitamin K1 was needed to be given early.
作者 郝建萍 哈力达.牙森
机构地区 新疆医科大学第一附属医院
出处 《中国现代医学杂志》 CAS CSCD 北大核心 2011年第20期2456-2458,共3页 China Journal of Modern Medicine
关键词 维生素K缺乏 凝血酶原时间 活化部分凝血活酶时间 vitamin K Deficiency PT APTT
分类号 R591.49 [医药卫生—内科学]
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参考文献10

  • 1陆再英,钟南山.内科学[M].第7版.北京:人民卫生出版社,2008:925-931.
  • 2ANDRE C, GUYON C, THOMASSIN M, et al. Association mechanism between a series of rodenticide and humie aeid:a frontal analysis is to support the biological data [J]. J Chromatogr B Analy Technol Biomed Life Sci, 2005, 820(1): 9-14.
  • 3SPAHIt JE, MAUL JS, RODGERS GC, et al. Superwarfarin poisoning:a report of two eases and review of the literature[J]. Am J Hematol, 2006, 82: 1-5.
  • 4PODOLSKY DK, ISSELBACHER KJ, BRAUNWALD KJ. Harrison's Principles of Internal Medicine [M]. 15th ed. New York: McGraw-Hill Professional Publishing, 2001, 1341-1351.
  • 5薛峰,杨仁池.维生素K环氧化物还原酶亚单位1的研究进展[J].中华血液学杂志,2008,29(3):213-215. 被引量：4
  • 6WATTS RG, CASTLEBERRY RP, SADOWSKI JA, et al. Accidental poisoning with a superwarfarin compound (brodifacoum) in a child[J]. Pediatrics, 2000, 105(2): 402-404.
  • 7WEITZEL JN, SADOWSKI JA, FURIE BC, et al. Surreptitious ingestion of a long-acting vitamin K antagonist/rodenfieide,brodi- facoum: clinical and metabolic studies of three eases [J]. Blood, 1990, 76(12): 2555-2559.
  • 8HOLLINGER BR, PASTOOR TP. Case management and plasma half-life in a case of brodifacoum poisoning[J]. Arch Intern Med, 1993, 153: 1925-1928.
  • 9ROST S, FREGIN A, IVASKEVICIUS V, et al. Mutation in VKORCI cause warfarin resistance and multiple coagulation factor deficiency type 2[J]. nature, 2004, 427(6974): 537-541.
  • 10RIEDER M J, REINER AP, GAGE BF, et al. Effect of VKO- RC1 haplotypes on transeriptional regulation and warfarin dose [J]. N Engl J Med, 2005, 352(22): 2285-2293.

二级参考文献22

  • 1Chu PH, Huang TY, Williams J ,et al. Purified vitamin K epoxide reduclase alone is sufficient for conversion of vitamin K epoxide to vitamin K and vitamin K to vitamin KH2. Proc Natl Acad Sci U S A ,2006,103 : 19308-19313.
  • 2Oldenburg J, von Brededow B, Fregin A, et al. Congenital deficiency of vitamin K dependent coagulation factors in two families presents as a genetic defect of the vitamin K-epoxide-reductase-complex. Thromb Haemost ,2000,84:937-941.
  • 3Fregin A, Rost S, Wolz W, et al. Homozygosity mapping of a second gene locus for hereditary combined deficiency of vitamin K-dependent clotting factors to the centromeric region of chromosome 16. Blood ,2002,100:3229-3232.
  • 4Rost S, Fregin A, Ivaskevicius V, et al. Mutations in VKORC1 cause warfarin resistance and multiple coagulation factor deficiency type 2. Nature,2004,427:537-541.
  • 5Li T, Chang CY, Jin DY, et al. Identification of the gene for vitamin K epoxide reductase. Nature ,2004,427:541-544.
  • 6Tie JK, Nicchitta C ,von Heijne G, et al. Membrane topology mapping of vitamin K epoxide reductase by in vitro translation/cotranslocation. J Biol Chem,2005,280 : 16410-16416.
  • 7Goodstadt L,Ponting CP. Vitamin K epoxide reductase:homology, active site and catalytic mechanism. Trends Biochem Sci, 2004, 29 : 289 -292.
  • 8Rost S, Fregin A, Htinerberg M, et al. Site-directed mutagenesis of coumarin-type anticoagulant-sensitive VKORCI: evidence that highly conserved amino acids define structural requirements for enzymatic activity and inhibition by warfarin. Thromb Haemost, 2005,94:780-786.
  • 9Jin DY,Tie JK,Stafford DW. The conversion of vitamin K epoxide to vitamin K quinone and vitamin K quinone to vitamin K hydroquinone uses the same active site cysteines. Biochemistry, 2007,46: 7279-7283.
  • 10Oldenburg J, Watzka M, Rost S,et al. VKORC1 : molecular target of coumarins. J Thromb Haemost,2007, 5 Suppl 1 : 1-6.

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中国现代医学杂志
2011年 第20期

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