绝经后女性高血压伴糖耐量减低患者骨密度分析

Analysis of bone mineral density in postmenopausal patients with hypertension and impaired glucose tolerance

目的:观察绝经后女性原发性高血压(EH)伴糖耐量减低(IGT)对骨密度(BMD)的影响,并探讨其可能发病机制。方法:入选绝经后女性107例,其中单纯IGT组(A组)28例、EH伴IGT组(B组)24例、对照组(C组)55例。比较A组和B组骨质疏松的患病率、检测3组实验室指标与各部位BMD,并分析各部位BMD与相关危险因素之间的相关性。结果:B组腰椎骨质疏松患病构成比高于A组(P<0.05);B组L1、L2、L3、L4的BMD显著低于A组(P<0.05);A、B组L2、L3、L4、Ward's三角区的BMD均低于C组(P<0.05)。绝经年限、餐后2 h血糖、体质指数与BMD相关。结论:绝经后EH伴IGT女性部分腰椎、Ward's三角区的BMD显著降低,BMD与绝经年限、餐后2 h血糖水平、平均动脉压呈直线负相关;与体质指数呈正相关。

Objective：To investigate the changes of bone mineral density（BMD） in postmenopausal patients with essential hypertension（EH） and impaired glucose tolerancee（IGT）,and explore the possible mechanism. Method：The total of 107 postmenopausal female patients were divided into 3 groups： pure IGT group（A group,28 cases）,IGT and EH group（B group,24 cases）,control group（C group,55 cases）.Prevalence of osteoporosis were compared between the A and B groups.BMD and laboratory indicators were compared among the three groups.The correlation between BMD and risk factors was evaluated by pearson correlation analysis. Result：The prevalence of lumber osteoporosis in IGT combined EH group were higher than that of the pure IGT group（P0.05）;there were significant differences in lumbar L1,L2,L3,L4 BMDs between the pure IGT group and IGT combined EH group（P0.05 respectively）;BMDs in lumbar L2,L3,L4 and Ward＇s triangle in two experimental group were significantly lower than that in the control group（P0.05 respectively）.Pearson correlation analysis showed that BMDs were associated with menopause age,2 h postprandial plasma glucose,body mass index（BMI）. Conclusion：BMDs in some lumbar spine and Ward＇s triangle were significantly reduced in postmenopa usal patients with hypertension and impaired glucose tolerance.BMDs were negatively correlated with postmenopausal age,postprandial plasma glucose and mean arterial pressure but positively correlated with BMI.