肝癌衍生生长因子在乳腺癌中的表达及其临床意义

Hepatoma-Derived Growth Factor Expression and Its Clinical Significance in Breast Cancer

目的探讨肝癌衍生生长因子(HDGF)在乳腺癌中的表达及其临床意义。方法应用免疫组织化学SP法检测113例乳腺癌和32例乳腺良性增生性病变中HDGF表达及乳腺癌中人类表皮生长因子受体2(HER-2)、雌激素受体(ER)和孕激素受体(PR)的表达。比较HDGF与ER、PR、HER-2表达以及其与临床病理因素之间的关系。采用Kaplan-Meier法对不同HDGF表达水平乳腺癌患者进行单因素生存分析,利用Cox模型进行多因素生存分析。结果腺癌组织中HDGF高表达率显著高于乳腺良性增生性病变组织(P<0.01)。HDGF表达与患者的年龄、绝经状况及病理类型、ER、PR表达无明显相关性(P>0.05),但与患者瘤体大小,淋巴结转移,远处转移、临床分期及HER-2表达显著相关(P<0.01或0.05)。5年生存率HDGF低表达组明显高于高表达组(P<0.01)。HDGF是乳腺癌预后的一项重要因素(RR=1.263,P<0.05)。结论 HDGF高表达与乳腺癌的预后不良有关,可作为一个新的判断乳腺癌预后的参考指标。

Objective To evaluate the expression of Hepatoma-derived growth factor（HDGF） and its clinical implication in breast cancer.Methods The expression of HDGF was detected by immunohistochemical method in 113 breast cancer and 32 breast hyperplasia tissues.At the same time,the expressions of human epidermal growth factor receptor 2（HER-2）,estrogen recaptor（ER） and progesterone（PR） were detected in breast cancer.The relationships between HDGF,ER,PR and HER-2 with clinical data were analyzed by multivariate analysis and Kaplan-Meier.Results Over-expression rate of HDGF in breast cancer tissues was higher than that in breast hyperplasia tissues（P0.01）.There were no relationship between the expression of HDGF and age,pathological type,menostasis,ER and PR expression（P0.05）.However,HDGF expression was significantly correlation with tumor size,lymphnode metastasis,distant metastasis and HER-2 expression（P0.01 or 0.05）.Patients with low HDGF expression had a higher 5-year survival rates than those with HDGF over-expression（P0.01）.Multivariate analysis showed that HDGF was an important prognostic factor for breast cancer（RR=1.263,P0.05）.Conclusion The over-expression of HDGF was a novel biomarker involved in the poor prognosis of breast cancer.