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NFAT在乳腺癌中的研究进展 被引量：1

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摘要 0引言 乳腺癌是危害女性健康的常见恶性肿瘤,近年来在我国发病率呈上升趋势。乳腺癌的发生发展与机体多种因素有关。NFAT（Nuclear factor of activated T cells,活化T细胞核因子）被广泛的发现于各种免疫细胞和组织,而且在乳腺癌以及其微环境的细胞如内皮细胞中发现了NFAT的广泛表达。
作者 钟燕军 胡汉宁 杨桂 涂建成 喻明霞
机构地区 武汉大学中南医院检验科基因检测中心
出处 《肿瘤防治研究》 CAS CSCD 北大核心 2011年第8期960-962,共3页 Cancer Research on Prevention and Treatment
基金 国家自然科学基金资助项目(30901308) 博士点基金-新教师类资助项目(20090141120025)
关键词 NFAT 乳腺癌 钙流 转移 血管生成
分类号 R737.9 [医药卫生—肿瘤]
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参考文献30

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同被引文献14

  • 1承海,糜漫天,张乾勇,陈丹.n-3 PUFA依赖的跨膜型肿瘤坏死因子-α真核表达载体的构建[J].第三军医大学学报,2005,27(1):28-30. 被引量：3
  • 2张乾勇,糜漫天,承海.鱼油联合肿瘤坏死因子α对乳腺癌移植瘤影响[J].中国公共卫生,2005,21(11):1313-1314. 被引量：2
  • 3Yan D, Qin N,Zhang H, et al. Expression of TNF - alpha leadersequence renders MCF - 7 tumor cells resistant to the cytotoxicityof soluble TNF - alpha[ J]. Breast Cancer Res Treat, 2009, 116(1): 91-102.
  • 4Janji B, Vallar L, Al Tanoury Z, et al. The actin filament cross -linker L - plastin confers resistance to TNF - alpha in MCF - 7breast cancer cells in a phosphorylation - dependent manner[ J].Cell Mol Med, 2010, 14(6A) : 1264 -1275.
  • 5Iniguez MA, Punz6n C, Nieto R, et al. Inhibitory effects of sigma -2receptor agonists on T lymphocyte activation [J].Front Pharmacol,2013,4: 23.
  • 6Strait KA, Stricklett PK, Kohan KM, et al. Identification of twonuclear factor of activated T - cells (NFAT) - response elementsin the 5' - upstream regulatory region of the ET - 1 promoter[ J].Biol Chem, 2010, 285(37) ; 28520 -28528.
  • 7Wang Y, Wang X, Zhao H, et al. Clusterin confers resistance toTNF - alpha - induced apoptosis in breast cancer cells through NF -kappaB activation and Bel - 2 overexpression [ J ]. Chemother,2012,24(6) : 348 -357.
  • 8Nagamoto - Combs K, Combs CK. Microglial phenotype is regula-ted by activity of the transcription factor, NFAT (nuclear factor ofactivated T cells) [ J]. Neurosci, 2010,30(28) : 9641 -9646.
  • 9Madeleine MM, Johnson LG, Malkki M, et al. Genetic variationin proinflammatory cytokines IL6, IL6R,TNF - region, and TN-FRSF1A and risk of breast cancer [ J ]. Breast Cancer Res Treat,2011, 129(3); 887 -899.
  • 10Li X,Zhao Y,Zhang Y, et al. Tumor necrosis factor a stimulatesHer -2 cleavage by activated caspase - B [ J]. Cell Physiol Bio-chem, 2012,30(4) : 889 -897.

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肿瘤防治研究
2011年 第8期

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