子宫内膜异位症患者免疫功能的变化与分析

An Analysis on the Changes of lmmunological Function in Endometriosis Patients

对子宫内膜异位症（ 简称内异症） 患者的免疫指标进行测定， 探讨内异症患者体液与细胞免疫的状态， 并分析抗子宫内膜抗体（ＥＭＡｂ） 、卵巢肿瘤相关抗原（ＣＡ１２５） 在内异症诊断方面的意义。检测内异症患者的外周血免疫球蛋白（ＩｇＡ、ＩｇＭ、ＩｇＧ） ， 补体Ｃ３ 、Ｃ４ 和Ｔ淋巴细胞亚群（ＣＤ３ 、ＣＤ４ 、ＣＤ８） 的含量及ＥＭＡｂ、ＣＡ１２５ ， 并与盆腔炎组、对照组比较。结果表明内异症组与盆腔炎组外周血免疫球蛋白ＩｇＡ、ＩｇＭ、ＩｇＧ均升高， 与对照组相比， 有显著性差异（ Ｐ＜ ０ ．０１） ； 内异症组与盆腔炎组相比， 仅ＩｇＧ 含量降低（ Ｐ＜ ０．０１） ，ＩｇＭ、ＩｇＡ含量无显著性差异（ Ｐ＞ ０ ．０５）。内异症组与对照组相比， Ｃ３ 、Ｃ４ 有升高趋势， 但无显著性差异（ Ｐ＞０ ．０５） ； ＣＤ４／ＣＤ８ 较对照组升高（ Ｐ＜ ０．０５） ， ＣＤ３ 、ＣＤ４ 均无明显变化。内异症患者ＥＭＡｂ 阳性率５９．１％ ，ＣＡ１２５ 升高者仅１４％ ； 盆腔炎患者ＥＭＡｂ 阳性率０ ％ ， ＣＡ１２５ 升高者占５０％ 。认为内异症患者存在免疫功能的亢进， 尤以体液免疫亢进为主， 其程度与盆腔炎患者相近。ＥＭＡｂ 在内异症诊断方面具较高的特异性。

Objective:To test the immunological indexes in endometriosis (EM) patients, and analyze the significance of two indexes, EM antibody (EMAb) and ovarian cancer related antigen (CA 125 ), on the diagnosis of EM. Method:The contents of immunoglobulin (IgA,IgM,IgG), complements (C 3,C 4),subgroup of T cell (CD 3,CD 4,CD 8),EMAb and CA 125 were tested in EM group (Group Ⅰ),pelvic inflammation group (Group Ⅱ) and control group(Group Ⅲ). Results: As compared with Group Ⅲ, the contents of Ig rise significantly in Group I and Group Ⅱ (P< 0.01 );compared with Group Ⅱ,IgG drops in Group Ⅰ (P< 0.01 );compared with Group Ⅲ, there is a rising trend of C 3 and C 4 in Group I, but the difference is not significant (P> 0.05 );CD 4/CD 8 rises significantly (P< 0.05 ).Positive incidence of EMAb in EM patients is 59.1% , CA 125 14%,pelvic inflammation (PI) EMAb 0%, CA 125 50%.Conclusion: The results indicated that there is an enhancement of immunologic function in EM patients, specially the humoral immunity, similar to that in PI. The specificity of EMAb is relatively high for the diagnosis of EM, but that of CA 125 is not.