补气活血中药对肺源性心脏病的血液粘度、氧自由基和血浆NO的影响

Effect of Qi-reinforcing and Blood-flow-activating Herbal Medicine on Blood Viscosity, Oxygen Free Radical and Plasma Nitric Oxide in Patients with Pulmonary Heart Disease

为探讨补气活血中药对肺源性心脏病（ 肺心病） 患者的血液粘度、氧自由基和血浆一氧化氮（ＮＯ）的影响， 将５１ 例肺心病患者随机分为两组， 其中治疗组（２６ 例） 在西医常规治疗基础上加用黄芪注射液和复方丹参注射液治疗， 对照组（２５ 例） 只采用西医常规治疗， 观察两组治疗前后血液流变学、红细胞超氧化物歧化酶（ＳＯＤ） 的活性、血浆中丙二醛（ＭＤＡ） 和ＮＯ的变化。结果表明， 治疗组治疗后全血低切、全血高切和血浆粘度均较治疗前降低（ 均Ｐ＜ ０．０１） ， 红细胞压积亦低于治疗前（ Ｐ＜ ０ ．０５）， 红细胞ＳＯＤ活性、血浆ＮＯ含量高于治疗前（均Ｐ＜ ０ ．０１）， 而血浆ＭＤＡ 比治疗前降低（ Ｐ＜ ０ ．０５） ； 对照组上述指标亦有改善， 但无统计学意义。提示黄芪注射液和复方丹参注射液合用能通过降低肺心病患者血液粘稠度、增高ＳＯＤ的活性、降低血浆ＭＤＡ含量。

To explore the effect of qi_reinforcing and blood-flow-activating herbal medicine, Radix Astragali seu Hedysari Injection and Radix Salviae Miltiorrhizae Injection, on blood viscosity, oxygen free radical and plasma nitric oxide (NO) in patients with pulmonary heart disease (PHD), 51 cases of PHD were randomly allocated to two groups. Group Ⅰ(25)was treated with routine treatment and Group Ⅱwith Radix Astragali seu Hedysari Injection and Radix Salviae Miltiorrhizae Injection.Blood rheology,RBC superoxide dismutase (SOD),plasma malonyldialdehyde (MDA) and NO were observed before and after the treatment. The results showed that in Group Ⅱ,the whole blood low-shearing viscosity and high-shearing viscosity, plasma viscosity, MDA and hemotocrit (HCT) were decreased after treatment (P< 0.01 or P< 0.05 ), and the activity of SOD and NO level were increased (P< 0.05 ).In Group I, the post-treatment differences of the above parameters were insignificant. It is concluded that Radix Astragali seu Hedysari Injection combined with Radix Salviae Miltiorrhizae Injection can decrease blood viscosity and MDA level, and increase the activity of SOD and NO content in patients with PHD, thus the high pulmonary pressure is reduced.