诱导性多潜能干细胞(iPS细胞)的研究进展

The Progress of Induced Pluripotent Stem Cells(iPS Cells)

通过转染特定的基因组合可以将已分化的体细胞重编程为多潜能干细胞,这种干细胞称为诱导性多潜能干细胞(induced pluripotent stem cells,iPS cells)。这是近年来干细胞研究领域最令人瞩目的一项新的干细胞制备技术。iPS细胞的出现不仅为体细胞重编程去分化机制的研究提供了新的模型,而且为疾病发生发展相关机制研究与特异的细胞治疗带来了新的希望。就当前获取iPS细胞的方法、影响iPS细胞转化率和多能性维持的一些因素及其研究进展进行综述。

Differentiated somatic cells can be reprogramed to induced pluripotent stem cells（iPS cells）by thansfection of a combination of specific genes,which is the most notable stem cell manufacturing technology in the stem cell research field in recent years.iPS cell not only is new model for the study of reprogramming mechanism of somatic cell,but also bring a new hope for the research of disease development mechanism and specific cell therapy.The preparation methods of iPS cells and related factors that influence transformation rate of iPS cells and pluripotency maintenance were summarized.