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胰岛素类似物强化治疗对新诊断2型糖尿病患者胰岛β细胞功能的影响 被引量:1

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摘要 对22例新诊断T2DM患者进行为期2周的胰岛素类似物诺和锐强化治疗,分析比较治疗前后空腹血糖(FPG)及餐后2h血糖(2h PG)、糖化血红蛋白(HbA1c)、静脉葡萄糖耐量试验(IVGTT)时胰岛素及C肽分泌水平和胰岛素曲线下面积、胰岛素分泌指数(Homaβ)。结果FPG、2hPG和HbA1c均较治疗前显著降低(P<0.01);空腹及IVGTT时每一时间点的胰岛素和C肽浓度均较治疗前明显升高(P<0.01);胰岛素曲线下面积及Homaβ值均明显增加(P<0.01)结论早期胰岛素类似物强化治疗可显著改善新诊断T2DM患者胰岛β细胞功能。
出处 《实用糖尿病杂志》 2011年第4期37-38,共2页 Journal of Practical Diabetology
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  • 1叶新华,杜云峰,高剑波,薛云,李德,成金罗.短期诺和锐强化治疗对初诊2型糖尿病患者胰岛β细胞功能的影响[J].中华糖尿病杂志(1006-6187),2005,13(2):114-117. 被引量:87
  • 2张梅,邓尚平.2型糖尿病早期胰岛素应用的几个问题[J].中华糖尿病杂志(1006-6187),2005,13(6):471-472. 被引量:45
  • 3Andrews W J, Vasquez B, Nagulesparan M, et al. Insulin therapy in obese, non insulin dependent diabetes induces improvements in insulin action and secretion that are maintained for two weeks after insulin withdrawal[J]. Diabetes,1984,33(7):634-642.
  • 4Weyer. Dificiency in AIR predict IGT and Type 2 diabetes. Diabetes Care, 2001,24 : 89-94.
  • 5Haffner SM, Miettinen H, Gaskill SP, et al. Decreased insulin secretion and increased insulin resistance are independently related to the 7-year risk of NIDDM in Mexican-Americans. Diabetes, 1995,44: 1386-1391.
  • 6Bruce DG, Chisholm DJ, Leonare H, et al. Physiological importance of deficiency in early prandial insulin secretion in non-in-sulin-dependent diabetes. Diabetes, 1988,37: 736-743.
  • 7Bruttomesso D, Pianta A, Mari A, et al. Restoration of early rise in plasma insulin levels improves the glucose tolerance of type 2 diabetic patients. Diabetes, 1999,48: 99-105.
  • 8Ilkova H, glaser B, Tunckale A, et al. Induction of long-term glycemic control in newly diagnosed type 2 diabetic patients by transient intensive insulin treatment. Diabetes Care, 1997,20:1353-1356.
  • 9Walton C, Godsland IF, Proudler AJ, et al. Effect of body mass index and fat distribution on insulin sensitivity, secretion, and clearance in nonobese healthy men. J Clin Endocrinol Metab,1992,75: 170-175.
  • 10Purrello F, Rabuazza AM. Metabolic factors that affect betacell function and survival. Diabet Nutr Metab, 2000, 13: 84-91.

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