慢性阻塞性肺疾病气道黏液高分泌机制及中医药干预作用

Mechanism of airway mucus hypersecretion in COPD and intervention by TCM

气道黏液高分泌是慢性阻塞性肺疾病(COPD)的重要病理生理特征,可加重气道阻塞,并导致下呼吸道感染难以控制,已被认为是影响COPD病死率和预后的独立危险因素。气道黏液高分泌的结构基础主要是气道上皮杯状细胞的广泛化生,而黏蛋白基因表达的增强则直接导致黏液高分泌,后者受多种因素的调节,形成一个复杂的信号转导网络。近年来,在COPD气道黏液高分泌病理生理机制及中医药研究方面取得了明显进展,为COPD防治提供了新的方向与药物。

Airway mucus hypersecretion is a pathophysiological feature of chronic obstructive pulmonary diseases.It results in airway obstruction and contributes significantly to lower respiratory infection,morbidity and mortality.The progress in mucus hypersecretion gives new direction and drug for preventing and treating chronic obstructive pulmonary diseases.