风湿性多肌痛患者免疫状态的研究

Studies on status of immunity in patients with polymyalgia rheumatica

目的： 探讨风湿性多肌痛（ＰＭＲ） 患者免疫状态的变化。方法： 采用ＡＰＡＡＰ法和单向免疫扩散法， 对８ 例ＰＭＲ 患者的外周血Ｔ细胞亚群及血清免疫球蛋白进行测定， 并以１０ 例正常人作对照。结果： ＰＭＲ患者外周血中ＣＤ＋４细胞数比正常对照组高（ Ｐ ＜０－００１） ， ＣＤ＋８ 细胞数明显低于正常对照组（ Ｐ＜０－００１）， ＣＤ＋４ ／ＣＤ８ 细胞比值明显升高（ Ｐ＜ ０－００１）， ＰＭＲ 患者血清ＩｇＧ明显高于正常对照组（ Ｐ ＜ ０－００１）。结论： ＰＭＲ 患者存在着免疫调节紊乱，ＣＤ＋８ 细胞数的降低在ＰＭＲ发病中可能起着重要作用。

Objective: To investigate the changes of immunity in patients with polymyalgia rheumatica.Methods:The T-cell subsets determination in the peripheral blood and the immunoglobulin levels in serum were measured by alkaline phosphatase-antialkaline phosphatase and simple immunoagar diffusion in 8 patients with PMR and 10 normal Persons. Results:The percentage of CD 4 positive cells and the ratio of CD + 4/CD + 8were increased in these patients with PMR(P<0 001). The percentage of CD 8 positive cells in the patients with PMR were significantly lower than those of the controls(P<0 001).Whereas the lgG level in serum were increased compared with normal controls(P<0 001). Conclusion:These findings indicate that there was immunoregulative disorder in the patients with PMR.The reduction of CD 8maybe play an important part in pathogenesis of PMR.