类人胶原蛋白对强脉冲光治疗雀斑术后修复效果的定量评价

Quantitative assessment of repairing effect of freckles using human-like collagen after intense pulsed light treatment

目的观察应用类人胶原蛋白对强脉冲光治疗雀斑术后的修复作用，应用VISIA皮肤图像分析仪和SOFT5．5皮肤性质测试仪对作用效果进行定量评价。方法50例患者随机分为两组，一组治疗后应用类人胶原蛋白面膜1周（每日1贴），1周后改为2次／周，共3周；另一组作为平行对照，两组分别于治疗后1周和1个月后，用VISIA皮肤图像分析仪和SOFT5．5皮肤性质测试仪对患者皮肤性质进行定量分析和评价。结果VISIA数据显示蛋白组1周后与对照组比较，纹理、毛孔和紫质均有统计学意义（P〈0．05），其中毛孔1个月后与对照组比较有统计学意义（P〈0．05）；SOFT数据显示蛋白组1周后与对照组比较，水分和油脂均有统计学意义（P〈0．05），蛋白组1个月后与对照组比较，水分、弹性和油脂均有统计学意义（P〈0．05），治疗后1个月蛋白组与治疗前比较，pH有统计学意义（P〈0．05）。结论类人胶原蛋白在强脉冲光治疗后1周内可以明显提高皮肤水分和油脂，对皮肤纹理和毛孔有所改善；长期应用类人胶原蛋白可以增加皮肤水分和弹性，在一定程度上对改善皮肤毛孔有所作用。

Objective To evaluate the quantitative assessment of repairing effect of freckles using human-like collagen after intense pulsed light （IPL） treatment using VISIATM complexion analysis system and SOFT 5.5 skin property system. Methods Fifty patients with freckles were divided randomly into two groups. One group was a- dopted with facial mask of human-like collagen （1 piece/d） for 1 week after IPL treatment and then two times per week for 3 weeks. The other group was used as parallel control group. After one week and one months were evaluated and analyzed using VISIATM complexion analysis system which was performed at 1 week and 1 month respectively, SOFT 5.5 skin property system was used to perform the quantitative analysis of skin. Results Compared with the control group, VISIA data in the collagen group, texture, pore and porphyropsin had statistical significance at 1 week （ P 〈 0. 05） and pore also had statistical significance at 1 month （ P 〈 0.05） ; SOFY data appeared, moisture and greases had significant difference at 1 week （ P 〈 0. 05 ） and moisture, elasticity and greases had significant difference at 1 month （P〈0.05）. The pH in the collagen group had statistical significance at 1 month comparing with that before treatment （ P 〈 0. 05）. Conclusion Human-like collagen could obviously increase skin moisture and greases and improve skin texture after IPL treatment at the first week. Long term application of human-like collagen could increase skin moisture and improve skin texture in a certain degree.