摘要
目的:探讨脂蛋白受体相关蛋白5、6(LRP-5、LRP-6)在溃疡性结肠炎(UC)相关癌组织中的表达及意义.方法:以溃疡性结肠炎伴不典型增生(UD)和溃疡性结肠炎相关癌(UCAC)为病例组,溃疡性结肠炎(UC组)和散发性大肠癌(SCRC组)为对照组,应用免疫组织化学S-P法检测各组肠黏膜组织中LRP-5、LRP-6的表达.结果:5例UCAC中,LRP-5和LRP-6蛋白阳性表达率均明显高于对照组,与对照UC、SCRC比较差异有统计学意义(LRP-5:80.00%vs23.33%,40.00%;LRP-6:80.00%vs16.67%,45.00%,均P<0.01).在15例UD组中,LRP-5和LRP-6蛋白阳性表达分别为14例(93.33%)及13例(86.67%),与对照组UC、SCRC比较差异有统计学意义(P<0.05).结论:LRP-5、LRP-6在UCAC的发病机制中可能起着较重要的作用,并可能作为一个早期生物学标记物来提示瘤变的可能.
AIM： To explore the clinical significance of expression of low-density lipoprotein receptorrelated protein 5 （LRP-5） and LRP-6 in ulcerative colitis （UC）-associated cancer （UCAC）.
METHODS： Immunohistochemistry was used to detect the expression of LRP-5 and LRP-6 in 15 cases of UC-associated atypical hyperplasia（UD）, 5 cases of UCAC, 30 cases of UC and 20 cases of sporadic colorectal cancer （SCRC）.
RESULTS： The positive rate of LRP-5 expression in UCAC was the same as that of LRP-6 （4/5, 80.00%）. The positive rates of LRP-5 and LRP-6 were significantly higher in UCAC than in UC （LRP-5： 80.00% vs 23.33%, 40.00%; LRP-6： 80.00% vs 16.67%, 45.00%, all P 〈 0.01）. The positive rates of LRP-5 and LRP-6 expression in 15 cases of UD were 93.33% （14/15） and 86.67% （13/15）, respectively, significantly higher than those in UC and SCRC （all P 〈 0.05）.
CONCLUSION： LRP5 and LRP6 may play a significant role in the development of UCAC and can be used as early markers to hint dysplasia.
出处
《世界华人消化杂志》
CAS
北大核心
2011年第20期2128-2132,共5页
World Chinese Journal of Digestology
基金
内蒙古卫生厅医疗卫生科研计划基金资助项目
No
20100068~~
