细胞周期重启与阿尔茨海默病

Relationship of cell cycle re-entry and Alzheimer’s disease

阿尔茨海默病(Alzheimer’s disease,AD)是最常见的神经退行性疾病,占成人痴呆症的60%以上。研究表明在受到异常刺激时分化成熟的细胞可以跨过G0/G1检查点进入G1期,并在S期发生DNA复制,有的细胞甚至能够到达G2期,但是最终却不能进入M期完成有丝分裂的整个过程。中枢神经元通常被认为处于终末分化状态,意味着它们不再进入细胞周期。然而,越来越多的研究显示AD患者脑中神经元存在细胞周期的重启,细胞周期重启可导致神经元死亡,细胞周期重启与AD的病理变化关系密切。

Alzheimer’s disease(AD) is the most common neurodegenerative disease and accounts for more than 60% of the dementia in adults.It is found that terminally differentiated cells upon abnormal stimuli may pass the G0/G1 checkpoint into G1 phase and replicate DNA in S phase and that some cells may even arrive at G2 phase.However they eventually can not enter M phase and complete mitosis.Neurons in the adult central nervous system have classically been described as being in a terminally differentiated state meaning that they no longer return the cell cycle.However,more and more studies show that there is a cell cycle re-entry phenotype in the neurons of AD brain.Cell cycle re-entry may lead to neuron death and is closely related with the pathological changes of AD.