期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

沉默交配型信息调节因子2同源蛋白Sirt1 被引量：1

Research progress of Sirt1
原文传递
导出
摘要 沉默交配型信息调节因子2同源蛋白1(silent mating type information regulation 2 homolog 1,Sirt1)是哺乳动物中与酵母沉默信息调节蛋白2(silencing information regulator 2,Sir2)高度同源的蛋白质,它是一种依赖NAD+的III类组蛋白去乙酰化酶(HDAC III),在细胞分化、衰老、凋亡、DNA损伤修复、能量及内分泌代谢调节中起重要作用,同时在基因沉默、表观遗传学修饰、转录调控及信号转导调节中发挥重要的生物学功能。本文对其近年的研究进展做一概述。 Sirt1,the mammalian homolog of Sir2,is a NAD-dependent class III histone deacetylase(HDAC).It plays an important role in cell differentiation,aging,apoptosis,DNA damage repair,energy and endocrine metabolism as well as in the control of many biological processes,such as gene silencing,epigenetic modification,transcriptional regulation,signal transduction.This review will mainly summarize the research progress of Sirt1.
作者 何丹 杜文婷 任思冲 刘戟
机构地区 四川大学华西基础医学与法医学院生物化学与分子生物教研室 四川中医药高等专科学校药学与检验系医学检验教研室
出处 《生命的化学》 CAS CSCD 北大核心 2011年第4期577-581,共5页 Chemistry of Life
关键词 SIRT1 衰老 DNA损伤修复 MIRNA human sirt1 aging DNA damage repair miRNA
分类号 Q51 [生物学—生物化学]
  • 相关文献

参考文献35

  • 1Kaeberlein Met al. The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms. Gene Dev, 1999, 13:2570-2580.
  • 2Blander Get al. The Sir2 family of protein deacetylases. An Rev Biochem, 2004, 73:417-435.
  • 3Arunachalam G et al. Sirt1 regulates oxidant- and cigarette smoke-induced eNOS acetylation in endothelial cells: Role of resveratrol. Biochem Biophysl Res Commun, 2010, 393:66-72.
  • 4Gerhart-Hines Z et al. Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC-1 α. EMBO J, 2007, 26:1913-1923.
  • 5Lomb DJ et al. Sirtuins regulate key aspects of lipid metabolism. Biochim Biophys Acta, 2010, 1804:1652-1657.
  • 6Tang BL et al. Is systemic activation of Sirtl beneficial for ageing- associated metabolic disorders? Biochem Biophysl Res Commun, 2010, 391:6-10.
  • 7Bordone Let al. Sirtl regulates insulin secretion by repressing UCP2 in pancreatic beta cells. PLoS Biol, 2006, 4:210-220.
  • 8Schwer Bet al. Conserved metabolic regulatory functions of sirtuins. Cell Metabolism, 2008, 7:104-112.
  • 9Salminen A et al. SIRT1 :regulation of longevity via autophagy, CellSignal, 2009, 21:1356-1360.
  • 10Yen WL et al. How to live long and prosper: autophagy, mitochondria, and aging. Physiology, 2008, 23:248-262.

同被引文献18

  • 1白亮,庞卫军,杨公社.Sirt1:一种新的脂肪细胞和肌细胞调控因子[J].遗传,2006,28(11):1462-1466. 被引量：5
  • 2Ando S, Mori Y, Nakamura K, et al. Characteristics of lipid ae cumulation types in five spiecies of fish [J]. Nippon Suisan Gakkaishi, 1993,59(9) : 1559-1564.
  • 3Cheng H L, Mostoslavsky R,Saito S,et al. Developmental de- fects and p53 hyperacetylation in Sir2 homolog (SIRT1)-defi-cient mice[J].Developmental Biology, 2003,100 (19) : 10794- 10799.
  • 4Frye R A. Phylogenetic classification of prokaryotic and eu- karyotic Sir2-1ike proteins [J].Biochemical and Biophysical Re- search Communications, 2000,273 (2) : 793-798.
  • 5Langley E,Pearson M, Faretta M, et al. Human SIR2 deacety- lates p53 and antagonizes PML/p53-induced cellular senescence [J]. EMBO J,2002,21(10) :2383-2396.
  • 6Luo J,Nikolaev A Y,Lmai S,et al. Negative control of p53 by Sir2 alpha promotes cell survival under stress [J]. Cell, 2001, 107(2) :137 148.
  • 7Motta M C, Divecha N, Lemieux M, et al. Mammalian SIRT1 represses forkhead transcription factors [J]. Cell, 2004, 116 (4) :551-563.
  • 8Kitamura Y I,Kitamura T,Kruse J P,et al. FoxO1 protects a- gainst pancreatic beta cell failure through NeuroD and MafA induction [J]. Cell Metab, 2005,2(3) : 153-163.
  • 9Yang T,Fu M,Pestell R, et al. SIRTI and endocrine signaling [J]. Trends Endocrinol Metab,2006,17(5) : 186-191.
  • 10Libert S,Pointer K,Bell E L,et al. SIRT1 activates MAO-A in the brain to mediate anxiety and exploratory drive [J]. Cell, 2011,147(7) : 1459-1472.

引证文献1

二级引证文献1

生命的化学
2011年 第4期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部