酶启动和调控自组装超分子水凝胶

Enzyme-triggered and -controlled self-assembly of supramolecular hydrogel

超分子间的弱相互作用使自组装超分子水凝胶的结构比较容易改变。用酶启动和调控超分子水凝胶的自组装不仅能在原位上对超分子水凝胶结构进行调整和控制,而且具有很好的生物选择性,有望制造出生物医学上所需要的材料,并能够控制生物体系中一些重要的生物过程。本文对酶启动和调控自组装超分子水凝胶的两类过程进行了总结,并以磷酸酯酶、β-内酰胺酶、嗜热菌蛋白酶、脂肪酶、基质金属蛋白酶和磷酸酯酶/激酶等酶为例,综述了如何设计和使用酶来启动和调控小分子的自组装超分子水凝胶。

The weak noncovalent interactions enable the self-assembled supramolecular hydrogels to easily response to a variety of external stimuli.One emerging concept consists of making use of the catalytic action of enzymes to control self-assembly of supramolecular hydrogel,which not only can regulate and control the structure of supramolecular hydrogel in situ,but also shows the good biological selectivity to make potential biomaterials in biomedical applications.Moreover,enzymatic spatiotemporal regulation promises a unique opportunity to integrate molecular self-assembly in water with natural biological processes.In this paper,two possible scenarios to enzyme-controlled self-assembly supramolecular hydrogel are summarized.Taking phosphatase,thermolysin,β-lactamase,lipase,matrix metalloprotease,and phosphatase/kinase as examples,we also illustrated for the design and application of enzyme-triggered and-controled formation of supramolecular hydrogels through the self-assembly of small molecules.