玻璃酸钠联合rhEGF滴眼液治疗白内障摘除术后干眼的疗效

Effect of hyaluronic acid sodium combined with rhEGF eye drops on dry eye after cataract extraction

目的:探讨玻璃酸钠滴眼液联合重组人表皮生长因子(rhEGF)滴眼液治疗白内障囊外摘除术后干眼的临床疗效。方法:选择白内障囊外摘除术后有干眼症状的患者42例60眼,随机分为治疗组和对照组两组,每组21例30眼治疗组采用玻璃酸钠滴眼液联合rhEGF滴眼液滴眼,对照组单独使用玻璃酸钠滴眼液。记录患者用药前和用药后2,4wk的干眼症状评分,裂隙灯下观察泪膜破裂时间(BUT)、泪液分泌试验(SchirmerⅠtest,SⅠt)、荧光素染色(FL)情况。结果:治疗前两组干眼症状评分、BUT,SⅠt,FL无显著性差异(P>0.05),用药后2,4wk,治疗组干眼症状评分、BUT,SⅠt,FL与对照组比较,均有显著性差异(P<0.01)。结论:玻璃酸钠滴眼液联合rhEGF滴眼液治疗白内障囊外摘除术后干眼疗效优于单独使用玻璃酸钠滴眼液。

AIM：To evaluate the effects of hyaluronic acid sodium eye drops combined with recombined human epidermal growth factor（rhEGF） eye drops on dry eye after extracapsular cataract extraction METHODS：All 42 cases（60 eyes） with dry eye symptom after the excision of extracapsular cataract were chosen and randomly divided into two groups,the treatment group and control group.In the treatment group,the patients were treated by hyaluronic acid sodium eye drops and rhEGF eye drops.In the control group,the patients were treated by hyaluronic acid sodium eye drops.The subjective dry eye symptoms,fluorescein staining（FL）,the time of tear secretion（SchirmerⅠtest,SⅠt） and tear break-up time（BUT） were observed by the slit lamp before treatment,the second and the fourth week after treatment.RESULTS：There was no statistical difference between groups before treatment（P0.05）.After treatment,the subjective dry eye symptoms,FL,S Ⅰt and BUT were significantly different（P0.01）.CONCLUSION：Hyaluronic acid sodium eye drops combined with rhEGF eye drops can be effective to relieve the dry eye symptoms after extracapsular cataract excision.