代谢组学研究针灸关键问题的初步策略分析与探讨

Primary Anylasis on the Methodology and Strategies for Studying Mechanisms of Acu-moxibustion by Using Metabonomics

代谢组学是后基因时代出现的一门新兴"组学",近年来代谢组学技术被日益广泛地运用于中医药研究领域,但针对针灸作用规律与机制的代谢组学实验研究尚处于初步探索阶段,鲜有文献报道。本文阐述了代谢组学在系统生物学中的独特优势,及其在现代中医药领域的广泛研究基础,探讨将代谢组学与中医、针灸契合的整体性、动态性等研究特点应用到现代针灸研究之中,对应用代谢组学解决临床研究中假针刺、时间针灸、针灸重大疾病及优势病种的机制研究、针灸处方配伍规律等现代针灸研究关键难题进行了初步的探索与策略分析。

Metabonomics is a newly emerging modern technology in the Post-genome era and has been being used widely in the study on modern Chinese medicine. But it have been rarely used in the study on acupuncture therapy. In the present paper, the authors introduce the unique advantages of metabonomics in the systemtic biology and its widespread studying basis in the field of modern Chinese medicine. Metabonomics and Chinese medicine including acupuncturology are of some similar characteristics such as entirety, comprehensiveness and dynamic changes. Moreover, the authors make a primary discussion and strategic analysis on the key issues of researches about sham acupuncture, chrono-acupuncture, mechanisms of acu-moxibustion underlying improvement of clinical severe disorders and various indications problems, regularities of combination of acupoints in different recipes, etc. by using metabonomics.