期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

砷代谢相关酶及其基因多态性研究进展 被引量：1

Research progress on arsenic metabolism related enzymes and their gene polymorphism
原文传递
导出
摘要 地方性砷中毒是一种严重危害健康的地方病,研究发现,高砷暴露环境下的个体并不都患病,提示除环境因素外,个体的遗传易感性在砷中毒的发病过程中可能也起着重要作用。砷在体内的代谢过程涉及许多酶促和/或非酶促反应过程,现在研究较多的砷代谢酶促反应3种相关酶是谷胱甘肽S转移酶(GSTO 1-1)、嘌呤核苷磷酸化酶(PNP)、三价砷甲基转移酶(CYT19/AS3MT),围绕上述酶及其基因多态性展开综述。 Endemic arsenism is an endemia that seriously affected people＇s health.Researches disclosed that despite some people exposed to high concentration of arsenic,but they were not sick,suggesting that individual susceptibility may also play some important role in the pathogenesis of arsenism.The metabolic process of arsenic in the body involved both enzymatic and non-enzymatic reaction,recent studies focused on glutathione S transferase Omega 1-1（GSTO 1-1）,purine nucleoside phosphorylase（PNP）and trivalent arsenic methyltransferase（CYT19/AS3MT）.The arsenic metabolism related enzymes and their gene polymorphism were reviewed in this paper.
作者 侯文胜 裴秋玲
机构地区 中国石油集团石油职业卫生技术服务中心 山西医科大学公共卫生学院毒理学教研室
出处 《中国工业医学杂志》 CAS 北大核心 2011年第4期272-276,共5页 Chinese Journal of Industrial Medicine
关键词 地方性砷中毒 谷胱甘肽S转移酶(GSTO1-1) 嘌呤核苷磷酸化酶(PNP) 三价砷甲基转移酶(CYT19/AS3MT) 基因多态性 endemic arsenism glutathione S transferase Omega 1-1（GSTO 1-1） purine nucleoside phosphorylase（PNP） arsenite methyltransferase（CYT19/AS3MT） gene polymorphism
分类号 R599 [医药卫生—内科学]
  • 相关文献

参考文献32

  • 1梁冰,张爱华,奚绪光,黄晓欣.GSTO基因多态性与燃煤污染型砷中毒易感性的关系[J].环境与职业医学,2007,24(2):129-132. 被引量：9
  • 2金银龙,梁超轲,何公理,曹静祥,马凤,王汉章,应波,吉荣娣,中国地方性砷中毒分布调查协作组.中国地方性砷中毒分布调查(总报告)[J].卫生研究,2003,32(6):519-540. 被引量：125
  • 3Andrewes P,Kitchin K T,Wallace K.Dimethylarsine and trimethyl-arsine are potent genotoxins in vitro. Chem Res Toxieol . 2003
  • 4Radabaugh TR,Sampayo Reyes A,Zakharyan R A,et al.ArsenatereductaseⅡ.Purine nucleoside phosphorylase in the presence of di-hydrolipoic acid is a route for reduction of arsenate to arsenite in mam-malian systems. Chemical Research in Toxicology . 2002
  • 5Nemeti B,Csanaky I,Gregus Z.Arsenate reduction in human eryth-rocytes and rats—Testing the role of purine nucleoside phosphorylase. Toxicological Sciences . 2003
  • 6Nemeti B,Gregus Z.Reduction of arsenate to arsenite by humanerythrocyte lysate and rat liver cytosol—Characterization of a glutathio-neand NAD-dependent arsenate reduction linked to glycolysis. Toxicological Sciences . 2005
  • 7Schmuck E M,Board P G,Whitbread A K,et al.Characterizationof the monomethylarsonate reductase and dehydroascorbate reductaseactivities of omega class glutathione transferase variants:implicationsfor arsenic metabolism and the age-at-onset of Alzheimer s andParkinson s diseases. Pharmacogenetics and Genomics . 2005
  • 8De Chaudhuri S,Ghosh P,Sarma N,et al.Genetic variants associ-ated with arsenic susceptibility:study of purine nucleoside phospho-rylase,arsenic (+3)methyltransferase,and glutathione-S-transfer-ase omega genes. Environmental Health Perspectives . 2008
  • 9Engstrom K S,Broberg K,Concha G,et al.Genetic polylnor-phisms influencing arsenic metabolism:Evidence from Argentina. Environmental Health Perspectives . 2007
  • 10Lindberg A L,Kumar R,Goessler W,et al.Metabolism of low-dose inorganic arsenic in a central European population:influence ofsex and genetic polymorphisms. Environmental Health Perspectives . 2007

二级参考文献10

  • 1潘尚霞,杨淋清.谷胱甘肽硫转移酶人群基因多态性及相关疾病[J].中国预防医学杂志,2006,7(4):365-368. 被引量：10
  • 2梁冰,张爱华,奚绪光,黄晓欣.谷胱甘肽硫转移酶M1和T1基因多态性与燃煤型砷中毒发病的关系[J].中国地方病学杂志,2007,26(1):6-8. 被引量：13
  • 3SCHMUCK E M,BOARD P G,WHITBREAD A K,et al.Characterization of the monomethylarsonate reductase and dehydroascorbate reductase activities of Omega class glutathione transferase variants:implications for arsenic metabolism and the age-at-onset of Alzheimer's and Parkinson's diseases[J].Pharmacogenet Genomics,2005,15(7):493-501.
  • 4ZAKHARYAN R A,ADRIANA S R,SHEILA M H,et al.Human monomethylarsonic acid (MMA (V)) reductase is a member of the glutathione-S-transferase superfamily[J].Chem Res Toxicol,2001,14:1015-105.
  • 5WHITBREAD A K,TETLOW N,EYRE H J,et al.Characterization of the human Omega class glutathione transferase genes and associated polymorphisms[J].Pharmacogenetics,2003,13(3):131-144.
  • 6ARNING L,JAGIELLO P,WIECZOREK S,et al.Glutathione S-Transferase Omega 1 variation does not influence age at onset of Huntington's disease[J].BMC Med Genet,2004,24:5-7.
  • 7MARAHATTA S B,PUNYARIT P,BHUDISAWASDI V,et al.Polymorphism of glutathione S-transferase Omega gene and risk of cancer[J].Cancer Lett,2005,28:1-6.
  • 8YU L,KALLA K,GUTHRIE E,et al.Genetic variation in genes associated with arsenic metabolism:glutathione S-transferase omega 1-1 and purine nucleoside phosphorylase polymorphisms in European and indigenous Americans[J].Environ Health Perspect,2003,111:1421-1427.
  • 9MARNELL L L,GARCIA-VARGAS G G,CHOWDHURY U K,et al.Polymorphisms in the human monomethylarsonic acid (MMA (V))reductase/hGSTO1 gene and changes in urinary arsenic profiles[J].Chem Res Toxicol,2003,16(12):1507-1513.
  • 10TANAKA-KAGAWA T,JINNO H,HASEGAWA T,et al.Functional characterization of two variant human GSTO 1-1s (Ala140Asp and Thr217Asn)[J].Biochem Biophys Res Commun,2003,301:516-520.

共引文献132

同被引文献20

  • 1Wilson D, Hooper C, Shi X. Arsenic and lead in juice: apple, citrus, and apple-base[J].Environ Health, 2012,75(5):14-20.
  • 2Davis MA, Mackenzie TA, Cottingham KL, et al. Rice consumption and urinary arsenic concentrations in U.S. children[J]. Environ Health Perspect, 2012,120(lO):1418-1424.
  • 3Merola RB, Kravchenko J, Rango T, et al. Arsenic exposure of rural populations from the Rift Valley of Ethiopia as monitored by keratin in toenails[J].Expo Sci Environ Epidemiol, 2013, 10(6):77-79.
  • 4Rango T, Bianchini G, Beccahva L, eta]. Geochemistry and water quality assessment of central Main Ethiopian Rift natural waters with emphasis on source and occurrence of fluoride and arsenic[J].Afr Earth Sci 2010,57(13):479-491.
  • 5A poshianH V, Zakharyan R A, Avram MD, et al.A review of the enzymology of arsenic metabolism and a new potential role of hydrogen peroxide in the detoxication of the trivalent arsen ic species[J].Tox-cology and Applied Pharmacology, 2004,198 (1):327-335.
  • 6Adair B M, Waters S B, Devesa V, et aZ Comonalities inmetabolism of arsenicals [J]. Env iron Chem, 2005, 2 (3) : 161-166.
  • 7NakayamaK, Moriwaki K, Imai T, et aLMutation of GDP-mannose-4, 6-dehydratase in colorectal cancer metastasis[J].PLoS One, 2013,8(7):702-708.
  • 8Moriwaki K, Noda K, Furukawa Y, et aZ Deficiency of GMDS leads to escape from NK cell-mediated tumor surveillance through modulation of TRAIL signaling[J].Gastroenterology, 2009, 137(1):188-198.
  • 9Moriwaki K, Shinzaki S, Miyoshi E. GDP-mannose-4,6-dehydrat ase(GMDS)deficiency renders colon cancer cells resistant to tumor necrosis factor-related apoptosis-inducing lig and(TRAIL)receptor-and CD95-mediated apoptosis by inhibi ring complex II formation[J].Biol Chem, 2011,286(50):123- 133.
  • 10Chanda S, Dasgupta UB, Mazumder DG, et al. Human GMI)S gene fragment hyper methylation in chronic high level of arsenic exposure with and without arsenic induced cancer[J]. Springerp]us, 2013,24(2):557-558.

引证文献1

二级引证文献3

中国工业医学杂志
2011年 第4期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部