大米纳米淀粉的超声法制备及载药性研究

Study on nano rice starch preparation by ultrasound and its drug loading capability

用超声波联合微乳液法制备大米纳米淀粉,并对大米纳米淀粉的载药性进行研究。考察了药物初始浓度、载药时间、载药温度对大米纳米淀粉载药量的影响,并研究了大米纳米淀粉对药物的缓释作用。结果表明,阿霉素初始浓度为3.0 mmol/L、吸附时间30 min、吸附温度37℃时,大米纳米淀粉对阿霉素的吸附量最大,达85 mg/g。阿霉素原料2 h药物释放率为99.6%,而纳米淀粉在透析8 h后,药物释放率仅为73.9%。由此可知,由超声法制备的大米纳米淀粉作为药物载体具有较好的载药性并对药物有较好的缓释作用。

Nano rice starch was prepared by ultrasonic combined with mieroemulsion method, and its drug loading capability was studied. The effects of adriamycin initial concentration, adsorption time and temperature on drug adsorption of nano rice starch were investigated, as well as its drug sustained-release effect. The results indicated that the adriamycin adsorption of nano rice starch reached the maximum （85 mg/g） with 3.0 mmol/L initial adriamycin concentration,adsorption for 30 min at 37 ℃. After being dialyzed for 8 h,adriamycin release rate of nano starch was only 73.9%,compared to 99.60/oo of raw adriamycin for 2 h. It was concluded that nano rice starch prepared by ultrasound as drug carrier had good drug loading capability and sustained-release action.