不同运动方式对绝经后女性IL-6、TNF-α和hs-CRP的影响

Effects of Different Modes of Exercise Training on IL-6,TNF-α and hs-CRP in Post-menopausal Women

目的比较12周有氧运动或抗阻训练对绝经后女性白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)和高敏C-反应蛋白(hs-CRP)影响的差异,为制定特异性的运动处方提供依据。方法将符合标准的受试者随机分为有氧运动组(18人),抗阻训练组(17人)和对照组(20人)。有氧运动组和抗阻训练组进行每周3次、共12周的运动干预,对照组保持日常生活习惯不变。实验前后分别测定血清IL-6、TNF-α、hs-CRP等指标。结果 12周运动干预后,有氧运动组血清IL-6较运动前下降了13%(P<0.01),血清TNF-α(P>0.05)和hs-CRP(P>0.05)无显著性变化;抗阻训练组血清IL-6较运动前无显著性变化(P>0.05),但血清TNF-α和hs-CRP分别下降了11%(P<0.05)和26%(P<0.05)。对照组所有指标的变化不明显。相关分析显示,实验前hs-CRP基础值与BMI(r=0.36,P<0.01)、空腹血糖(r=0.23,P<0.05)和IL-6(r=0.22,P<0.01)正相关,与VO2max(r=-0.29,P<0.05)负相关;实验后hs-CRP的变化值与BMI的变化值(r=0.21,P<0.05)正相关。结论 绝经妇女慢性全身性炎症状态与其BMI、血糖水平和体内炎症因子的水平有关;12周有氧运动或抗阻训练均能有效改善绝经后女性慢性全身性炎症状态,但抗阻训练的效果优于有氧运动,其原因与BMI的改善有关。

Objective： The research is to investigate the effect of 12-week aerobic exercise or resistance training on interleukin-6（IL-6）,tumor necrosis factor-α（TNF-α） and high sensitivity C-reactive protein（hs-CRP） in post-menopausal women,providing evidence for specific exercise prescription.Methods： Individuals consistent with inclusion criteria were randomly divided into aerobic exercise group（n=18）,resistance training group（n=17） and control group（n=20）.Aerobic exercise group and resistance training group conducted a 12-week（3 times per week） exercise protocols while control group maintained their routine lifestyle.Serum IL-6,TNF-α and hs-CRP were obtained through measurement before and after intervention.Results： After 12 weeks intervention,serum IL-6 in aerobic exercise group decreased by 13%（P0.01） compared with pre-exercise,but serum TNF-α（P0.05） and hs-CRP（P0.05） did not change significantly.In resistance training group,serum TNF-α and hs-CRP reduced by 11%（P0.05） and 26%（P0.05） respectively compared with pre-exercise,while serum IL-6 did not modified.All indices in control group showed no significant difference Correlation analysis displayed that,at baseline,hs-CRP was positively correlated with BMI（r=0.36,P0.01）,fasting blood glucose（r=0.23,P0.05） and serum IL-6（r=0.22,P0.01） and was inversely correlated with VO2max（r=-0.29,P0.05）.Change in hs-CRP was positively correlated with the change in BMI（r=0.21,P0.05） after intervention.Conclusion： There was positive correlation between chronic system inflammation state and BMI,blood glucose and level of inflammatory factors in post-menopausal women.Either aerobic exercise or resistance training of 12 weeks was effective in improving chronic system inflammation state of post-menopausal women,but resistance training showed more effective as compared to aerobic exercise because of exercise-induced improvement of BMI.