阿奇霉素联合左氧氟沙星治疗社区获得性肺炎疗效分析

Effect of Azithromycin combined with levofloxac in the treatment of community acquired pneumonia

目的探讨阿奇霉素联合左氧氟沙星治疗社区获得性肺炎(CAP)的疗效,为临床用药提供参考。方法将120例社区获得性肺炎随机分为A组、B组和C组各40例,A组应用阿奇霉素治疗,B组应用左氧氟沙星治疗,C组联合应用阿奇霉素及左氧氟沙星治疗,疗程均为7～14d。观察3组患者临床疗效、病情变化、细菌清除率和不良反应。结果 C组痊愈率和总有效率均高于A、B组,差异有统计学意义(P<0.05);C组发热、啰音消退时间和血常规、肺部X线恢复时间均短于A组和B组,差异有统计学意义(P<0.05);C组细菌清除率为92.5%明显高于A、B组的67.5%和65.0%,差异有统计学意义(P<0.01);3组不良反应发生率比较差异无统计学意义(P>0.05)。结论阿奇霉素联合左氧氟沙星治疗CAP,疗效显著,病程短,不良反应少,是基层医疗机构较为适宜的临床用药方案。

Objective To explore the curative effect of azithromycin combined with levofloxac in the treatment of community acquired pneumonia（CAP）,and to provide basis for medication of community acquired pneumonia.Methods 120 CAP patients were randomly divided into group A,B,and C（40 patients in each）.Patients in group A and B were treated with azithromycin and levofloxac respectively,and patients in group C were treated with azithromycin combined with levofloxac.Curative effect,changes of patient＇s condition,clearance rate of bacterial,and adverse reactions were observed.Results The curative rate and total effective rate in group C were higher than those in group A and B,and the differences were significant（P0.05）.In terms of fade time of fever and rale,recovery time of routine blood test and lung x-ray examination,and clearance rate of bacterial in group C were all shorter than those in group A and B,and the differences were significant（P0.05）.Bacterial clearance rate in group C （92.5%） was higher than that in group A （67.5%） and B（65.0%）,and the differences were significant（P0.01）.There was no significant differences of adverse reaction in the three groups（P0.05）. Conclusion Azithromycin combined with levofloxac in the treatment of CAP can improve curative effect,cut down the course of disease,and don＇t increase adverse reactions.It′s an appropriate treatment for CAP patients in primary health care sector.