儿童B系急性淋巴细胞白血病CD20表达及临床意义

Clinical significance of children with CD20 antigen expression in B acute lymphoblastic leukemia

目的探讨儿童B系急性淋巴细胞白血病(B acute lymphoblastic leukemia,B-ALL)CD20抗原表达与初诊临床特征的关系。方法流式细胞仪直接免疫荧光法检测广西医科大学第一附属医院儿科血液病房2006年7月至2010年8月收治的初诊120例B-ALL患儿CD20抗原表达。结果 120例患儿中CD20抗原表达阳性率为25%,CD20抗原表达与性别、年龄、外周血白细胞数、血红蛋白水平、血小板数、FAB分型、染色体改变、初诊时中枢神经系统白血病发生、诱导化疗缓解第19天骨髓状态及临床危险度分型无关。结论 CD20+与CD20-的B-ALL患儿初诊临床表现基本相同,不具有更多高危特征。

Objective To investigate the relationship between the expression of CD20 antigen in children with B acute lymphoblastic leukemia（B-ALL） at first diagnosis and clinical characteristics.Methods The expression of CD20 antigen was measured in 120 patients who were the first diagnosis in hematopathy sickroom of the First Affiliated Hospital of Guangxi Medical University from July 2006 to Aug 2010 using direct immunofluorescence scan.Results Positive rate of 120 patients with CD20 antigen expression was 25%.No significant relationships were found between CD20 antigen expression and gender,age,peripheral blood leucocytes count,hemoglobin level,platelet count,FAB classification,chromosomal changes,central nervous system leukemia at diagnosis,marrow status of remission induction chemotherapy on day 19 and clinical risk classification.Conclusion Patients with CD20 ＋ and CD20-in B-ALL at first diagnosis are the same clinical characteristics and do not have more high-risk characteristics.