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和厚朴酚衍生物的合成以及细胞毒性和凋亡活性评价 被引量：1

Synthesis and Evaluation of Honokiol Derivatives on Cytotoxicity and Apoptosis in a Human Hepatoma Cell Line (HepG2)
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摘要 针对几个效果良好的和厚朴酚衍生物,在肝癌细胞(HepG2)上,应用MTT分析、细胞形态学分析、DNA碎片分析和细胞流式分析等方法,进行抗增殖和促凋亡活性评价研究。研究结果表明,化合物3a在HepG2细胞上展现了非常显著的抗增殖活性(半数抑制浓度为21.58微摩)和促进细胞凋亡作用。 In this current study,five representative honokiol derivatives（2a,2b,2c,3a and 3b） were further evaluated for their anti-proliferative and pro-apoptotic activity in HepG2 cells by MTT assay,cell morphology analysis,DNA fragmentation and flow cytometry analysis.Compound 3a exerted the most potent anti-proliferative effect with an IC50 value of 21.58 μM and pro-apoptotic activity in HepG2 cells.
作者 王田恩 马良 陈俐娟
机构地区 四川大学生物治疗国家重点实验室
出处 《四川化工》 CAS 2011年第4期10-14,共5页 Sichuan Chemical Industry
关键词 和厚朴酚衍生物 抗增殖活性 促凋亡活性 HEPG2 细胞株 honokiol derivatives anti-proliferative activity pro-apoptotic activity HepG2 cell lines
分类号 R284 [医药卫生—中药学] R285 [医药卫生—中药学]
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参考文献10

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  • 2Lo YC, Teng CM, Chen CF, Chen CC, Hong CY. Magnolol and honokiol isolated from Magnolia officinalis protect rat heart mitochondria against lipid peroxidation. Biochem Pharmacol 1994. 47: 549- 53.
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二级参考文献1

  • 1Richard F. Squires,Jinglu Ai,Michael-Robin Witt,Pia Kahnberg,Else Saederup,Olov Sterner,Mogens Nielsen.Honokiol and Magnolol Increase the Number of [3H]Muscimol Binding Sites Three-Fold in Rat Forebrain Membranes In Vitro Using a Filtration Assay, by Allosterically Increasing the Affinities of Low-Affinity Sites[J].Neurochemical Research.1999(12)

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四川化工
2011年 第4期

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